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Synthesized Cortisone

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TODAY IN HEALTH HISTORY

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From Thursday, Setember 21st .....

Synthesized Cortisone

In 1948, Kendall and Philip Hench created the first of the many

" miracle drugs " -which were actually synthesized hormones-to treat

rheumatoid arthritis and other diseases. Hench and Kendall, who each

headed a medical department at the Mayo Clinic in Rochester, Minn.,

realized that the adrenal glands play an important role in rheumatoid

arthritis. The two noticed that a woman with rheumatoid arthritis had a

lessening of symptoms while she was pregnant, and they worked to

discover what caused the change. They were able to isolate a hormone in

the cortex, or outer part, of the adrenal glands, which they called

cortisone. On Sept. 21, 1948, Hench administered a synthesized version

of cortisone developed by Kendall to a patient with arthritis. The two

researchers were awarded the Nobel Prize in physiology or medicine in

1950 for their achievements.

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