Guest guest Posted August 26, 2003 Report Share Posted August 26, 2003 Hello lists Please be advised that the new FluMist nasal vaccine states in its package insert, that there is monosodium glutamate (MSG) used in the buffer that stabilizes the allantoic fluid harvested from the chicken eggs containing the live influenza virus. Specifically, " the allantoic fluid of these eggs is harvested, clarified by centrifugation, and stabilized with buffer containing sucrose, potassium phosphate, and monosodium glutamate (0.47 mg/dose). " (1) What is potentially bothersome is the fact that the nerves in the nose are a direct pathway to the brain, and bypass the blood-brain barrier. See Fields Virology which states " the olfactory tract has long been recognized as (a) an alternative pathway to the CNS, and ( an important mode of spread after aerosol exposure. " In the case of flaviviruses (which are admittedly not the same as influenza viruses), the text continues: " Intranasal inoculation of flaviviruses may result in lethal encephalitis, presumably by direct infection of olfactory neurons and spread through the olfactory tract to the brain, whereas peripheral inoculation of the same virus strains does not result in neuroinvasion. However, olfactory neurons may also provide a route for CNS infection after peripheral virus infection. " (2) The point being, one might want to be very cautious regarding allowing things to be sprayed up one's nose. The package insert states that there are no preservatives in the vaccine per se, and that the virus is cultured on pathogen-free eggs. However, as previously discussed on these lists, the chicken genome itself may contain hidden retroviruses; and there is known to be significant amounts of animal DNA that is left in vaccines during the manufacturing process, not to mention other contamination possibilities. So, common sense might indicate that, for these reasons it might not be in one's best (healthful) interest to put these materials into one's nose. An ordinary flu shot might be a safer route (if necessary). Of course, this is not intended to constitute medical advice, but is meant to inform the reader of additional information in the public domain. References 1. The package insert can be reviewed at: http://www.medimmune.com then click on " more information " in the FluMist box; then click on " prescribing information here " for a PDF copy of the package insert. 2. Knipe, M, ed. Fields Virology. Philadelphia: Lippincott, 4th ed. 2001. P. 1057. Best wishes, Char ________________________________________________________________ The best thing to hit the internet in years - Juno SpeedBand! Surf the web up to FIVE TIMES FASTER! Only $14.95/ month - visit www.juno.com to sign up today! ATTENTION PLEASE: The Symphonic Health List is for learning different health and healing modalities and exchanging opinions and experiences, and not to give medical advice. It makes no representations regarding the individual suitability of the information contained in any document read or advice or recommendation offered which appears on this website and/or email postings for any purpose. The entire risk arising out of their use remains with the recipient. In no event shall the Symphonic Health list owner or its individual members be liable for any direct, consequential, incidental, special, punitive or other damages whatsoever and howsoever caused by someone following advice given without first thinking it through carefully, and running it past whatever health professional they deem necessary. Those people needing medical attention should seek qualified PROFESSIONAL MEDICAL ADVICE. Quote Link to comment Share on other sites More sharing options...
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