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FluMist vaccine (fwd)

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Hello lists

Please be advised that the new FluMist nasal vaccine states in its

package insert, that there is monosodium glutamate (MSG) used in the

buffer that stabilizes the allantoic fluid harvested from the chicken

eggs containing the live influenza virus. Specifically, " the allantoic

fluid of these eggs is harvested, clarified by centrifugation, and

stabilized with buffer containing sucrose, potassium phosphate, and

monosodium glutamate (0.47 mg/dose). " (1)

What is potentially bothersome is the fact that the nerves in the nose

are a direct pathway to the brain, and bypass the blood-brain barrier.

See Fields Virology which states " the olfactory tract has long been

recognized as (a) an alternative pathway to the CNS, and (B) an important

mode of spread after aerosol exposure. "

In the case of flaviviruses (which are admittedly not the same as

influenza viruses), the text continues: " Intranasal inoculation of

flaviviruses may result in lethal encephalitis, presumably by direct

infection of olfactory neurons and spread through the olfactory tract to

the brain, whereas peripheral inoculation of the same virus strains does

not result in neuroinvasion. However, olfactory neurons may also provide

a route for CNS infection after peripheral virus infection. " (2)

The point being, one might want to be very cautious regarding allowing

things to be sprayed up one's nose.

The package insert states that there are no preservatives in the vaccine

per se, and that the virus is cultured on pathogen-free eggs. However,

as previously discussed on these lists, the chicken genome itself may

contain hidden retroviruses; and there is known to be significant amounts

of animal DNA that is left in vaccines during the manufacturing process,

not to mention other contamination possibilities. So, common sense might

indicate that, for these reasons it might not be in one's best

(healthful) interest to put these materials into one's nose. An ordinary

flu shot might be a safer route (if necessary). Of course, this is not

intended to constitute medical advice, but is meant to inform the reader

of additional information in the public domain.

References

1. The package insert can be reviewed at: http://www.medimmune.com

then click on " more information " in the FluMist box; then click on

" prescribing information here " for a PDF copy of the package insert.

2. Knipe, M, ed. Fields Virology. Philadelphia: Lippincott, 4th

ed. 2001. P. 1057.

Best wishes,

Char

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