Hepatitis C;EASL Boceprevir A Highlight and A List Of Peer-Reviewed Journals

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Hepatitis C;EASL Boceprevir A Highlight and A List Of Peer-Reviewed Journals

As we know the FDA Panel will be reviewing the two experimental hepatitis C virus protease inhibitors ; Merck-Boceprevir, Vertex-Telaprevir in late April. Today on the blog boceprevir is in the spotlight with the help of NATAP, EASL and HIV and hepatitis.Just as a side note; Merck has registered the name Victrelis® as their trademark and has used it in the press release to announce their posters/abstracts which will be presented at the EASL meeting this month. .As noted previously on the blog, because the EASL has a media embargo in place until all data is presented and reviewed by attendees/physicians, I have provided my readers

with a few direct links to some of the "Boceprevir" posters available to the public through the EASL website..Today, with the wealth of information on the internet the HCV patient is educated and has become their own advocate. However, the majority of journals provided online are not "peer reviewed" and these patients hunger for substantial credible information. Although the liver meeting provides the HCV community with clinical data, this data presented at the EASL should be considered preliminary until it has been reviewed and published in a peer-reviewed publication. ( See below for a list of peer-reviewed journals.)These links will help you navigate your way through the EASL website.Upcoming Oral PresentationsAbstracts/Poster SessionsBoceprevir;P3.08D: Category 08d: Viral Hepatitis C: Clinical (new compounds, resistance)http://www1.easl.eu/easl2011/program/Posters/Abstract4.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract216.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract225.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract229.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract235.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract240.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract255.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract256.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract259.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract273.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract283.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract288.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract291.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract1072.htmhttp://www1.easl.eu/easl2011/program/Posters/Abstract1118.htmNATAP has put together this great information on Boceprevir that you'll find easy to understand;Simplified Explanation of the Phase 3 Studies of HCV Protease Inhibitor BoceprevirBoceprevir is a HCV protease inhibitor for patients with genotype 1, the more difficult to treat type of patients, that is expected to be publicly reviewed at an FDA hearing in April, approved and in the pharmacy by June this year 2011 and will be added to pegylated interferon/ribavirin as part of a 3 drug combination therapy; up until now standard-of-care therapy has been only peginterferon+ribavirin.With triple-drug therapy response rates are greatly increased.Early responses (called Response Guided Therapy) will allow many patients to be able to cut

the duration of therapy significantly by a number of months from the current 48 weeks to 28 or 36 weeks.A new pill developed by Merck for chronic hepatitis C virus (HCV) genotype 1, the hardest to treat form, significantly improves virologic cure rates when added to standard therapy and shortens treatment time for up to half of patients by three to five months.The pill, called boceprevir, is to be used in combination with standard therapy. The combination has been shown in two major studies to be significantly more effective than standard therapy for people undergoing HCV treatment for the first time as well as for people who previously did not attain a virologic cure by standard therapy alone (nonresponders).The combination of boceprevir and standard therapy also offers patients the opportunity to individually tailor how long they undergo treatment based on early responses to the drugs. This represents an approach to treating

HCV, called response-guided therapy (RGT)....continue reading............. Also from NATAP & HIV and Hepatitis ; Conference on Retroviruses and Opportunistic Infections - CROI 2011Boceprevir Improves SVR With PegIFN/RBV After Failure or Relapse With HCV-1Mark MascoliniAdding the HCV-NS3 protease inhibitor boceprevir to pegylated interferon plus ribavirin (PegIFN/RBV) significantly improved sustained virologic response (SVR) rates in HCV genotype 1-infected people with a history of nonresponse or relapse with PegIFN/RBV [1]. SVR rates were higher among relapsers than nonresponders, though 40% to 50% of nonresponders attained SVR with boceprevir plus PegIFN/RBV...continue reading..... From HIV and HepatitisHCV Protease Inhibitor Boceprevir Improves Response for Treatment-Naive and Non-respondersSUMMARY: Merck's investigational hepatitis C virus (HCV) protease inhibitor boceprevir improved sustained response rates when combined with pegylated interferon plus ribavirin in both previously untreated patients and those who were non-responders or relapsers after prior therapy, according to 2 Phase 3 studies presented at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) this month

in Boston...continue reading.....Looking For HCV Information OnlineHint;Look for web sites that end in .gov or .org rather than .comFrom HCV AdvocateThe Internet as a Source for informationThe Internet is a valuable tool. However, like any tool, one needs to know how to use it well. The following are some suggestions for how to use the Internet more effectively:Find out if the information comes from independent and not-for-profit sources, particularly from the U.S. federal government (e.g., National Institutes of Health (NIH), FDA), a general medical society (e.g., American Medical Association) or specialty or disease society

(e.g., American Association for the Study of Liver Diseases) is likely to be reliable.Commercial sources (e.g.,pharmaceutical companies) may be scientifically accurate, but may emphasize the positive aspects of a drug for marketing purposes...continue reading......A Few Of My Favorite Peer Reviewed Medical JournalsThe LancetYou are able to search for articles on hepatitis C and are able to view the abstracts free of charge; full text articles can be viewed for a fee.The New England Journal of MedicineMany abstracts and full text articles to view without a fee.Specialties & Topics ;Infectious DiseaseGastroenterologyThe World Journal of GastroenterologyAbstracts, and full text articles to view, again without a fee.List Of All Peer-Reviewed JournalsACS PublicationsAccounts of Chemical ResearchACS Chemical BiologyAnalytical ChemistryBiochemistryBioconjugate ChemistryBiomacromoleculesChemical Research in ToxicologyChemical ReviewsChemistry of MaterialsCrystal Growth & DesignEnergy & FuelsEnvironmental Science & TechnologyIndustrial & Engineering Chemistry Research Inorganic ChemistryJournal of Agriculture and Food ChemistryJournal of the American Chemical SocietyJournal of Chemical & Engineering DataJournal of Chemical Information and ModelingJournal of Chemical Theory and ComputationJournal of Combinatorial ChemistryJournal of Medicinal ChemistryJournal of Natural ProductsThe Journal of Organic ChemistryThe Journal of Physical Chemistry AJournal of Proteome ResearchLangmuirMacromoleculesMolecular PharmaceuticsNano LettersOrganic LettersOrganic Process Research & DevelopmentOrganometallicsAlcoholAcupuncture in MedicineAlcoholism: Clinical and Experimental ResearchAmerican Association of Pharmaceutical Scientists JournalsPharmaceuticalResearchPharmSci TechAHA Scientific PublishingArteriosclerosis, Thrombosis, and Vascular BiologyCirculationCirculation ResearchHypertensionStrokeAMA PublicationsArchives of Internal MedicineArchives of NeurologyArchives of OphthalmologyArchives of Otolaryngology-Head & Neck SurgeryArchives of Pediatrics & Adolescent MedicineArchives of SurgeryJAMAThe American Institute of Physics Online Journal ServiceThe American Journal of Clinical NutritionAmerican Journal on Mental RetardationAmerican Physical Society JournalsPhysical Review LettersOther APS Research JournalsAmerican Society of Nephrology JournalsJournal of the American Society of NephrologyClinical

Journal of the American Society of Nephrologyls of Emergency Medicinels of Internal Medicine The ls of ThoracicSurgery -->Annual Review of BiochemistryArthritis ResearchBioScienceBMJBreast Cancer ResearchCanadian Association of Radiologists JournalCanadian Journal of Rural MedicineCanadian Journal of SurgeryCanadian Medical Association Journal (CMAJ)CancerCatheterization and Cardiovascular InterventionsChinese Science BulletinCell

PressCancer CellCellChemistry & BiologyCurrent BiologyDevelopmental CellMolecular CellStructureImmunityNeuronCHESTCold Spring Harbor Laboratory PressGenes and DevelopmentGenome ResearchLearning & MemoryConservation BiologyCritical CareCurrent Research in Social PsychologyDrug and Alcohol DependenceDeutsches Ärzteblatt

InternationalElectronic Journal of BiotechnologyEndocrine-Related CancerEuropean Journal of EnocrinologyFederation of American Societies for Experimental BiologyFrontline GastroenterologyGastroenterologyHand SurgeryIEEE Intelligent SystemsIntellectual and Developmental DisabilitiesInternational Journal of Modern Physics A Internet ArchaeologyInvestigative Ophthalmology & Visual ScienceJAMAThe Journal of Biological ChemistryJournal of Biological SystemsJournal of Clinical InvestigationJournal of Clinical OncologyJournal of EndocrinologyThe Journal of Intelligent SystemsJournal of Molecular EndocrinologyJournal of NeuroscienceeJournal of Psychiatry & NeuroscienceJournal of the National Cancer Institute Journal of InternationalWildlife Law & PolicyJournal of Rehabilitation Research and DevelopmentJournal of Vascular and Interventional RadiologyJournal of VisionJournal of Young Investigators The LancetLiebert PublicationsAIDS Patient Care and STDsAIDS Research and Human RetrovirusesAlternative & Complementary TherapiesAntioxidants & Redox SignalingASSAY and Drug Development TechnologiesAstrobiologyBariatric Nursing and Surgical Patient CareBiosecurity and Bioterrorism: Biodefense Strategy, Practice, and ScienceBiotechnology Law ReportBreastfeeding MedicineCancer Biotherapy & RadiopharmaceuticalsCell Preservation TechnologyCloning and Stem CellsCyberPsychology & BehaviorDiabetes Technology & TherapeuticsDisease ManagementDNA and Cell BiologyElection Law JournalEnvironmental Engineering ScienceFoodborne Pathogens and DiseaseGaming Law ReviewGenetic TestingGenetic Engineering & Biotechnology NewsHigh Altitude Medicine & BiologyHuman

Gene TherapyHybridomaIndustrial BiotechnologyJournal of Aerosol MedicineJournal of Alternative and Complementary MedicineJournal of Child and Adolescent PsychopharmacologyJournal of Computational BiologyJournal of EndourologyJournal of Gynecologic SurgeryJournal of Interferon & Cytokine ResearchJournal of Laparoendoscopic & Advanced Surgical TechniquesJournal of Medicinal FoodJournal of NeurotraumaJournal of Ocular Pharmacology and TherapeuticsJournal of Palliative MedicineJournal of Women's HealthLymphatic Research and BiologyMedical AcupunctureMetabolic Syndrome and Related DisordersMicrobial Drug ResistanceObesity ManagementOligonucleotidesOMICS: A Journal of Integrative BiologyPediatric Asthma, Allergy & ImmunologyPhotomedicine and Laser SurgeryRejuvenation ResearchStem Cells and DevelopmentSurgical InfectionsSustainability: The Journal of RecordTelemedicine and e-HealthThyroidTissue Engineering, Parts A, B, CVector-Borne and Zoonotic DiseasesViral ImmunologyZebrafishPlanned Giving MentorPlanned Giving TodayMolecular Biology of the CellModern Physics Letters AModern Physics Letters BNatureNeurologyNew England Journal of MedicineNRC Research PressCanadian Journal of Forest ResearchCanadian Journal of Physics The Ohio Academyof Science -->Physiological GenomicsPopulation CouncilPopulation and Development ReviewStudies in Family PlanningProceedings of the National Academy of Sciences ReproductionRespiratory Research Science World Journal of GastroenterologyList can be found at; http://www.eurekalert.org/links.php?jrnl=A

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