Plasma carnitine is associated with fatigue in chronic hepatitis C but not in IBS

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Plasma carnitine is associated with fatigue in chronic hepatitis C but not in IBS

April's publication of the Alimentary Pharmacology & Therapeutics reports that plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome.

Fatigue is an important determinant of altered quality of life in patients affected by chronic hepatitis C or the irritable bowel syndrome (IBS).

Dr Anty and colleagues from France determined the contributory role of plasma levels of leptin and carnitine on fatigue in chronic hepatitis C and IBS.

The research team enrolled 81 patients with chronic hepatitis C, 42 with IBS and 44 healthy subjects.

Fatigue was evaluated using the Fatigue Impact Scale questionnaire.

Body composition was assessed through impedance analysis.

Patients with chronic hep C had lower plasma levels of total and free carnitine

Alimentary Pharmacology & Therapeutics

Plasma carnitine and leptin were measured.

The research team found that fatigue scores were significantly more elevated in patients with chronic hepatitis C and IBS than in healthy subjects.

The team noted that patients with chronic hepatitis C but not IBS, had significant lower plasma levels of total and free carnitine adjusted for fat mass compared with healthy subjects.

In patients with chronic hepatitis C and not with IBS, fatigue scores were negatively correlated with plasma levels of carnitine.

Levels of free carnitine were significantly and independently associated with the severity of fatigue in patients with chronic hepatitis C.

Dr Anty's team concludes, "In patients with chronic hepatitis C, the severity of fatigue is associated with a low level of carnitine, suggesting that an oral supplementation may be effective to relieve fatigue in chronic hepatitis C."

"The underlying mechanism of fatigue in IBS does not seem to involve carnitine."

http://www.gastrohep.com/news/news.asp?id=107979