Re: Lowered C3 Complement

[Guest guest]

Hmmm, I think I might have found part of the answer to my own question, with this. I'm going to go take a shot of B12!

Serum C3 Content in Vitamin B12-Deficient Rats

Masahiro Wada1, Tetsunori Kawata2, Kazuhiro Yamada3, Ulala Funada3, Masanori Kuwamori3, Masayoshi Endo3, Nobuo Tanaka4, Tadahiro Tadokoro3 and Akio Maekawa3

1 Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture, Setagaya-ku, Tokyo 156, Japan2 Faculty of Education, Okayama University, Tsushimanaka, Okayama 700, Japan3 Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture, Setagaya-ku,Tokyo 156, Japan4 Department of Internal Medicine, The Jikei University of Medicine, Katsushika-ku, Tokyo 124, Japan

Summary

As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.

Keywords

Vitamin B12-deficiency, Serum C3

International Journal for Vitamin and Nutrition Research, Band 68, 1998, Heft 2, © Verlag Hans Huber, Bern

----- Original Message -----

From: *~Patty~*

Sent: Saturday, July 19, 2003 9:28 PM

Subject: Lowered C3 Complement

I found this interesting when looking up "lowered C3 Complement" on the net. I had several blood tests come up with a lowered C3 complement, and as far as I know, it has not quite returned to normal. I wonder if this has something to do with my inability to fight off the bee venom? Anyone know how to enhance C3 levels?

Physiologic role of the complement system in host defense, disease, and malnutrition.Sakamoto M, Fujisawa Y, Nishioka K.Wayo Womens University, Chiba, Japan.The role of the complement system as a system merging early-phase innate immunity with later-phase acquired immunity has been established. C3 is a key protein of the complement system. It is activated in four pathways: (1) the alternative pathway, (2) the mannan binding protein pathway, (3) the C-reactive protein pathway, and (4) the natural IgM pathway in innate immunity. It is also activated in (1) a classic pathway, i.e., through an antigen-antibody complex, and (2) by injured host cells in acquired immunity. Activation of C3 results in a variety of immunologic reactions such as immune adherence, phagocytosis, antibody response, cytolysis, inflammation, and killing of pathogenic microorganisms. Pathologic pictures of the complement system in various diseases were reviewed. Attention was focused on hypocomplementemia in the malnourished state. In humans and in experimental animals, reduced complement levels, especially of C3, were observed in relation to lowered host defense against infection. Hypocomplementemia improved after nutritional rehabilitation with a concomitant improvement of the clinical picture and recovery of host resistance. Enhancement of C3 levels in malnourished or well-nourished rats resulted in heightened resistance against bacterial infections. On the basis of these experimental and clinical observations, we obtained clues to prevent or treat a compromised host defense system in malnourished states.

[Guest guest]

Patty

To be honest it may have something to do with your C3 issues but I

kind of doubt it. Allot of people get infections from insect bites. I

would not stress too much on it just get it taken care of and try to

avoid getting bit!

In , " *~Patty~* " <fdp@l...> wrote:

> I found this interesting when looking up " lowered C3 Complement " on

the net. I had several blood tests come up with a lowered C3

complement, and as far as I know, it has not quite returned to

normal. I wonder if this has something to do with my inability to

fight off the bee venom? Anyone know how to enhance C3 levels?

>

> Physiologic role of the complement system in host defense, disease,

and malnutrition.

>

> Sakamoto M, Fujisawa Y, Nishioka K.

>

> Wayo Womens University, Chiba, Japan.

>

> The role of the complement system as a system merging early-phase

innate immunity with later-phase acquired immunity has been

established. C3 is a key protein of the complement system. It is

activated in four pathways: (1) the alternative pathway, (2) the

mannan binding protein pathway, (3) the C-reactive protein pathway,

and (4) the natural IgM pathway in innate immunity. It is also

activated in (1) a classic pathway, i.e., through an antigen-antibody

complex, and (2) by injured host cells in acquired immunity.

Activation of C3 results in a variety of immunologic reactions such

as immune adherence, phagocytosis, antibody response, cytolysis,

inflammation, and killing of pathogenic microorganisms. Pathologic

pictures of the complement system in various diseases were reviewed.

Attention was focused on hypocomplementemia in the malnourished

state. In humans and in experimental animals, reduced complement

levels, especially of C3, were observed in relation to lowered host

defense against infection. Hypocomplementemia improved after

nutritional rehabilitation with a concomitant improvement of the

clinical picture and recovery of host resistance. Enhancement of C3

levels in malnourished or well-nourished rats resulted in heightened

resistance against bacterial infections. On the basis of these

experimental and clinical observations, we obtained clues to prevent

or treat a compromised host defense system in malnourished states.