more on silicone

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Note the last sentence: wherever there was bone destruction, siliconeparticles were found. This is not something that should be put in humanbodies!> J Hand Surg [Am] 1994 Jul;19(4):575-83>>> In vivo experimental analysis of silicone implants on bone and softtissue.>> Minamikawa Y, Peimer CA, Ogawa R, C, Sherwin FS>> Division of Hand Surgery, School of Medicine, Buffalo, NY.>> We report experimentally produced silicone microparticles (synovitis) in47> white rabbits and discuss the implications for clinical practice. Silastic> HP100 (Dow Corning , Arlington, TN) finger hinges (size 5) were> inserted in 20 rabbit's knees. The upper tibia was replaced with Swanson> design great toe implants in another 15 rabbits; articular cartilage was> removed and endosteal drilling was performed in 6 animals as a "sham"> arthroplasty. Small silicone blocks were inserted in the proximal tibial> endosteal canal of 6 others. Animals were followed by monthly x-ray films> and killed at 2, 4, 6, 12, and 16 months. Implant wear, bone surfaces, and> soft tissue were examined under the operating microscope and by light> microscopy; implant surfaces were examined with scanning electron> microscopy. X-ray changes included reactive endosteal bone formationaround> implant stems as early as 1 month postoperatively; at 2-3 months the new> bone line was clearest but it became progressively homogeneous and less> evident. Extensive cortical erosion around the stems was observed in one> third of the animals. Neither ossification nor lysis was observed aroundthe> silicone block. Proliferative synovitis was found at post-mortemexamination> beginning after 4 months; femoral condylar erosions were observed in most> animals after 12 months. Wherever there was bone destruction, silicone> particles were confirmed by x-ray spectrography.