Digestive problems and seizures

[Guest guest]

Fascinating post Zoe. My daughter Tasya only has seizures when she has

eaten foods that have caused an inflammatory response. We've noticed that

the only times she has a nocturnal seizure her stomach grumbles very loudly.

_____

From: [mailto: ]

On Behalf Of zoe88025

Sent: Friday, September 22, 2006 11:31 AM

Subject: [ ] Digestive problems and seizures

Another excerpt from the book mentioned in my last note:

Imitators of Epilepsy 15. Neuroendocrine, Metabolic and Toxic

Imitators of Epilepsy

Gastrointestinal Disease and Seizures

In patients with established celiac disease, epilepsy, with an

incidence of 1% to 6%, is the most frequent neurologic complication,

often associated with bilateral occipital calcifications (34). In

nontropical sprue or celiac disease, neurologic complications occur

in approximately 8% to 10% of adults with celiac disease (35). These

include epilepsy (associated particularly with occipital

calcifications and folate deficiency), cerebellar ataxia, peripheral

neuropathy, myositis, neuromyotonia, myasthenic syndrome, myelopathy,

and dementia accompanied by brain atrophy in adults. In celiac

disease, small bowel damage by gluten may lead to chronic

malabsorption. Today, celiac disease is diagnosed earlier and severe

malabsorption is rare. Possible mechanisms for CNS injury include

potential deficiencies of calcium, magnesium, and vitamins; genetic

factors (36); and isolated CNS vasculitis (37). Malabsorption may be

occult, and seizures may be the predominant feature. Restricted

dietary gluten may produce rapid improvement.

Neurologic symptoms are found in symptomatic and asymptomatic celiac

disease. In a general neurology clinic outpatient, Hadjivassiliou et

al. found positive antigliadin antibodies as a marker of gluten

sensitivity in a high proportion (57%) of patients with undiagnosed

neurologic diseases, especially patients with ataxia and peripheral

neuropathy (38). The frequency of proven celiac disease in this group

was 16%. It was suggested that gluten sensitivity should be

considered as a state of heightened immunologic T- and B-lymphocyte-

based responsiveness to ingested gluten proteins in genetically

predisposed individuals. The brain seems to be particularly

vulnerable.

Hadjivassiliou et al. suggested that focal white-matter lesions in

the brain may represent an extraintestinal manifestation of celiac

disease (38). These lesions may be ischemic in origin as a result of

a vasculitis or caused by inflammatory demyelination. Inflammatory

bowel disease (ulcerative colitis and Crohn's disease) is associated

with a low incidence of focal or generalized seizures. Not

surprisingly, generalized seizures frequently are associated with

infection or dehydration. In approximately half of patients with

focal seizures, a vascular basis is suspected (39).

Whipple's disease is a multisystem granulomatous disease caused by

Tropheryma whippellii (40). About 10% of patients have neurologic

involvement including dementia, ataxia, or oculomotor abnormalities.

As many as 25% of patients with CNS involvement have seizures (41).

Early treatment is crucial, as untreated patients with CNS

involvement usually die within 12 months (42). Some patients have

developed cerebral manifestations after successful antibiotic

treatment of gastrointestinal symptoms (43). Although several drugs

that cross the blood-brain barrier have been recommended for

treatment, such as chloramphenicol and penicillin (44), a high

incidence of CNS relapse led Keinath et al. (45) to recommend

penicillin 1.2m U, and streptomycin 1.0 g/day for 10 to 14 days,

followed by trimethoprim-sulfamethoxazole twice a day for 1 year.

However, treatment of the underlying disease may not lead to

prevention of seizures requiring AED treatment (46). Because

malabsorption is a significant problem, the use of a suspension or

elixir of the appropriate AED therapy is recommended. The most

effective drugs are trimethoprim-sulfamethoxazole and third-

generation cephalosporins (47,48).

[Guest guest]

Hi Mark,

I just sent someone to you via your company and to this group. At

the time I made the connection between food and my seizures, I didn't

know anything about inflammation. It is only slowly becoming

recognized as a factor in many disorders and diseases, such as MS,

allergies, and countless others. I hope Tasya continues to improve

and that you will see her seizure free.

Regards,

Zoe

>

> Fascinating post Zoe. My daughter Tasya only has seizures when she

has

> eaten foods that have caused an inflammatory response. We've

noticed that

> the only times she has a nocturnal seizure her stomach grumbles

very loudly.

>

>

>

>

> _____

>

> From:

[mailto: ]

> On Behalf Of zoe88025

> Sent: Friday, September 22, 2006 11:31 AM

>

> Subject: [ ] Digestive problems and seizures

>

>

>

> Another excerpt from the book mentioned in my last note:

>

> Imitators of Epilepsy 15. Neuroendocrine, Metabolic and Toxic

> Imitators of Epilepsy

>

> Gastrointestinal Disease and Seizures

>

> In patients with established celiac disease, epilepsy, with an

> incidence of 1% to 6%, is the most frequent neurologic

complication,

> often associated with bilateral occipital calcifications (34). In

> nontropical sprue or celiac disease, neurologic complications occur

> in approximately 8% to 10% of adults with celiac disease (35).

These

> include epilepsy (associated particularly with occipital

> calcifications and folate deficiency), cerebellar ataxia,

peripheral

> neuropathy, myositis, neuromyotonia, myasthenic syndrome,

myelopathy,

> and dementia accompanied by brain atrophy in adults. In celiac

> disease, small bowel damage by gluten may lead to chronic

> malabsorption. Today, celiac disease is diagnosed earlier and

severe

> malabsorption is rare. Possible mechanisms for CNS injury include

> potential deficiencies of calcium, magnesium, and vitamins; genetic

> factors (36); and isolated CNS vasculitis (37). Malabsorption may

be

> occult, and seizures may be the predominant feature. Restricted

> dietary gluten may produce rapid improvement.

>

> Neurologic symptoms are found in symptomatic and asymptomatic

celiac

> disease. In a general neurology clinic outpatient, Hadjivassiliou

et

> al. found positive antigliadin antibodies as a marker of gluten

> sensitivity in a high proportion (57%) of patients with undiagnosed

> neurologic diseases, especially patients with ataxia and peripheral

> neuropathy (38). The frequency of proven celiac disease in this

group

> was 16%. It was suggested that gluten sensitivity should be

> considered as a state of heightened immunologic T- and B-lymphocyte-

> based responsiveness to ingested gluten proteins in genetically

> predisposed individuals. The brain seems to be particularly

> vulnerable.

>

> Hadjivassiliou et al. suggested that focal white-matter lesions in

> the brain may represent an extraintestinal manifestation of celiac

> disease (38). These lesions may be ischemic in origin as a result

of

> a vasculitis or caused by inflammatory demyelination. Inflammatory

> bowel disease (ulcerative colitis and Crohn's disease) is

associated

> with a low incidence of focal or generalized seizures. Not

> surprisingly, generalized seizures frequently are associated with

> infection or dehydration. In approximately half of patients with

> focal seizures, a vascular basis is suspected (39).

>

> Whipple's disease is a multisystem granulomatous disease caused by

> Tropheryma whippellii (40). About 10% of patients have neurologic

> involvement including dementia, ataxia, or oculomotor

abnormalities.

> As many as 25% of patients with CNS involvement have seizures (41).

> Early treatment is crucial, as untreated patients with CNS

> involvement usually die within 12 months (42). Some patients have

> developed cerebral manifestations after successful antibiotic

> treatment of gastrointestinal symptoms (43). Although several drugs

> that cross the blood-brain barrier have been recommended for

> treatment, such as chloramphenicol and penicillin (44), a high

> incidence of CNS relapse led Keinath et al. (45) to recommend

> penicillin 1.2m U, and streptomycin 1.0 g/day for 10 to 14 days,

> followed by trimethoprim-sulfamethoxazole twice a day for 1 year.

> However, treatment of the underlying disease may not lead to

> prevention of seizures requiring AED treatment (46). Because

> malabsorption is a significant problem, the use of a suspension or

> elixir of the appropriate AED therapy is recommended. The most

> effective drugs are trimethoprim-sulfamethoxazole and third-

> generation cephalosporins (47,48).

>

>

>

>

>

>

[Guest guest]

all of this is VERY interesting to me. My daugther, aged 8, only has

seizures when she is constipated badly. The constipation also seems to cause a

rise

in her temperature. So, I assumed it was the temperature causing the seizure.

I guess it is all related.

Any help anyone can give to me on this, would be very appreciated. I stopped

giving her the miralax because it seemed to bother her. Now, she is eating a

chewable fiber pill. I know I need to get her a good multivitamin instead of

the typical sugary stuff with dyes in it.

Thanks, Carolyn

[Guest guest]

MEGA VEGIES AND FRUIT

LINDA

aigjr@... wrote:

all of this is VERY interesting to me. My daugther, aged 8, only has

seizures when she is constipated badly. The constipation also seems to cause a

rise

in her temperature. So, I assumed it was the temperature causing the seizure.

I guess it is all related.

Any help anyone can give to me on this, would be very appreciated. I stopped

giving her the miralax because it seemed to bother her. Now, she is eating a

chewable fiber pill. I know I need to get her a good multivitamin instead of

the typical sugary stuff with dyes in it.

Thanks, Carolyn

[Guest guest]

Hiya Carolyn,

I stopped using miralax also on my son .

Althought it helped with the pooping...It also intensified his seizure

activity.

{ His seizures were more INTENSE! Horrible!}

My Son's neuro was puzzled by that, because Miralax is all natural..but..I

guess that it just put a lot of strain on his body, added stress ...and

ERGO...Convulsive Seizures.

We give him an enema just about every week.

I am going to look into " home enema's " ...cuz the Fleets are just not cuttin'

it anymore.

Good Luck to you..

Blessings,

Dee

" When Life Gives Ya Lemons...Make lemonade "

and if a friend has Vodka...

Have a Party!

---------------------------------

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