RE: Impaired reproductive fitness in mothers of children with juvenile autoimmune arthropathies

[Guest guest]

Sorry, but I think that's a crock!

Christy (Abbie, 17 systemic, spondy, osteoporosis)

Impaired reproductive fitness in mothers of children with

juvenile autoimmune arthropathies

Impaired reproductive fitness in mothers of children with juvenile

autoimmune arthropathies

http://rheumatology.oxfordjournals.org/cgi/content/abstract/45/10/1282

Objective. To assess the reproductive fitness of mothers of children with

juvenile idiopathic arthritis (JIA).

Methods. A mail survey assessing pregnancy outcome was carried out among

mothers of children with JIA (JIA mothers) treated at a tertiary paediatric

rheumatology centre. The best friends of the JIA mothers served as controls.

Besides family history, sociodemographics and reproductive outcomes were

measured, including the number of pregnancies, pregnancy complications and

gestational age at the time of delivery.

Results. JIA mothers (n = 227) and controls (n = 235) had similar

sociodemographics and racial backgrounds. On average, JIA mothers reported a

greater number of conceptions than controls (3.5 vs 3.1) but had

significantly higher rates of pregnancy complications (25% vs 15%).

Corrected for differences in the absolute number of pregnancies between

groups, the chances of having a miscarriage [mean (S.D.), 0.12 (0.18) vs

0.09 (0.16)] or preterm delivery [0.08 (0.21) vs 0.04 (0.15)] were

significantly greater among JIA mothers than controls.

Conclusions. Mothers of children with JIA have impaired reproductive

fitness. This phenomenon is unlikely to be the result of difficulty with

conception but rather to be due to higher rates of pregnancy loss and

premature delivery.

Rheumatology Advance Access originally published online on April 4, 2006

Rheumatology 2006 45(10):1282-1287; doi:10.1093/rheumatology/kel092

M. Chaudhari1, M. B. Moroldo1, E. Shear1, P. Hillard2, S. D. 1, D.

Lan3, B. Huang3, H. I. Brunner1 and D. N. Glass1,

1Division of Rheumatology, 2Division of Adolescent Medicine and 3Center for

Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical

Center, University of Cincinnati, Cincinnati, OH, USA.

Correspondence to: D. N. Glass, Cincinnati Children's Hospital Medical

Center, Division of Rheumatology, E.2 4010, 3333 Burnet Avenue, Cincinnati,

OH 45229-3039, USA. E-mail: david.glass@...

[Guest guest]

Well, given that I had 6 pregnancies and six babies, all term and with the

smallest weighing 7 pounds, 8 ounces and the largest (at 38 weeks) weighing

10 pounds, 1 ounce, I have to wonder where they found the study subjects. I

know I was not among them!!

Liz

_____

From: [mailto: ] On Behalf

Of Georgina

Sent: Tuesday, October 10, 2006 1:10 PM

*JRA List

Subject: Impaired reproductive fitness in mothers of children with

juvenile autoimmune arthropathies

Impaired reproductive fitness in mothers of children with juvenile

autoimmune arthropathies

http://rheumatology

<http://rheumatology.oxfordjournals.org/cgi/content/abstract/45/10/1282>

..oxfordjournals.org/cgi/content/abstract/45/10/1282

Objective. To assess the reproductive fitness of mothers of children with

juvenile idiopathic arthritis (JIA).

Methods. A mail survey assessing pregnancy outcome was carried out among

mothers of children with JIA (JIA mothers) treated at a tertiary paediatric

rheumatology centre. The best friends of the JIA mothers served as controls.

Besides family history, sociodemographics and reproductive outcomes were

measured, including the number of pregnancies, pregnancy complications and

gestational age at the time of delivery.

Results. JIA mothers (n = 227) and controls (n = 235) had similar

sociodemographics and racial backgrounds. On average, JIA mothers reported a

greater number of conceptions than controls (3.5 vs 3.1) but had

significantly higher rates of pregnancy complications (25% vs 15%).

Corrected for differences in the absolute number of pregnancies between

groups, the chances of having a miscarriage [mean (S.D.), 0.12 (0.18) vs

0.09 (0.16)] or preterm delivery [0.08 (0.21) vs 0.04 (0.15)] were

significantly greater among JIA mothers than controls.

Conclusions. Mothers of children with JIA have impaired reproductive

fitness. This phenomenon is unlikely to be the result of difficulty with

conception but rather to be due to higher rates of pregnancy loss and

premature delivery.

Rheumatology Advance Access originally published online on April 4, 2006

Rheumatology 2006 45(10):1282-1287; doi:10.1093/rheumatology/kel092

M. Chaudhari1, M. B. Moroldo1, E. Shear1, P. Hillard2, S. D. 1, D.

Lan3, B. Huang3, H. I. Brunner1 and D. N. Glass1,

1Division of Rheumatology, 2Division of Adolescent Medicine and 3Center for

Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical

Center, University of Cincinnati, Cincinnati, OH, USA.

Correspondence to: D. N. Glass, Cincinnati Children's Hospital Medical

Center, Division of Rheumatology, E.2 4010, 3333 Burnet Avenue, Cincinnati,

OH 45229-3039, USA. E-mail: david.glass@ <mailto:david.glass%40cchmc.org>

cchmc.org

[Guest guest]

The study group seems pretty small with just over 200 participants

and having their best friends serve as the control group sounds a

bit odd....But anyway, I don't seem to fit the criteria either. Two

kids. full term just under 10 lbs and Aundrea was 3 weeks

early (intentionally) and weighed 6 lbs. 14 oz.

sonia (drea 11 systemic jra/gerd)-

-- In , " Christy Boos " <gazelle@...> wrote:

>

> Sorry, but I think that's a crock!

> Christy (Abbie, 17 systemic, spondy, osteoporosis)

> Impaired reproductive fitness in mothers of

children with juvenile autoimmune arthropathies

>

>

> Impaired reproductive fitness in mothers of children with

juvenile

> autoimmune arthropathies

>

http://rheumatology.oxfordjournals.org/cgi/content/abstract/45/10/128

2

>

> Objective. To assess the reproductive fitness of mothers of

children with

> juvenile idiopathic arthritis (JIA).

>

> Methods. A mail survey assessing pregnancy outcome was carried

out among

> mothers of children with JIA (JIA mothers) treated at a tertiary

paediatric

> rheumatology centre. The best friends of the JIA mothers served

as controls.

> Besides family history, sociodemographics and reproductive

outcomes were

> measured, including the number of pregnancies, pregnancy

complications and

> gestational age at the time of delivery.

>

> Results. JIA mothers (n = 227) and controls (n = 235) had similar

> sociodemographics and racial backgrounds. On average, JIA

mothers reported a

> greater number of conceptions than controls (3.5 vs 3.1) but had

> significantly higher rates of pregnancy complications (25% vs

15%).

> Corrected for differences in the absolute number of pregnancies

between

> groups, the chances of having a miscarriage [mean (S.D.), 0.12

(0.18) vs

> 0.09 (0.16)] or preterm delivery [0.08 (0.21) vs 0.04 (0.15)]

were

> significantly greater among JIA mothers than controls.

>

> Conclusions. Mothers of children with JIA have impaired

reproductive

> fitness. This phenomenon is unlikely to be the result of

difficulty with

> conception but rather to be due to higher rates of pregnancy

loss and

> premature delivery.

>

> Rheumatology Advance Access originally published online on April

4, 2006

> Rheumatology 2006 45(10):1282-1287;

doi:10.1093/rheumatology/kel092

> M. Chaudhari1, M. B. Moroldo1, E. Shear1, P. Hillard2, S. D.

1, D.

> Lan3, B. Huang3, H. I. Brunner1 and D. N. Glass1,

> 1Division of Rheumatology, 2Division of Adolescent Medicine and

3Center for

> Epidemiology and Biostatistics, Cincinnati Children's Hospital

Medical

> Center, University of Cincinnati, Cincinnati, OH, USA.

> Correspondence to: D. N. Glass, Cincinnati Children's Hospital

Medical

> Center, Division of Rheumatology, E.2 4010, 3333 Burnet Avenue,

Cincinnati,

> OH 45229-3039, USA. E-mail: david.glass@...

>

>

>

>

>

>