Re: Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Receiving Long-Term MTX for JIA

[Guest guest]

Does this mean that the MTX caused the lymphoma or helped it.

Veri

Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old

Receiving Long-Term MTX for JIA

Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Girl

Receiving Long-Term Methotrexate Therapy for Juvenile Idiopathic Arthritis.

http://www.jpho-online.com/pt/re/jpho/abstract.00043426-200609000-00013.htm;jses\

sionid=FrzVv4qp8GYypDJhPVNG0J8GQZ6Tvw1JB66tKspnflzq950Gp1Dy!-1455700262!-9498561\

45!8091!-1

Abstract:

We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with

polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis

treated with methotrexate (MTX), prednisone, and naproxen for 5 years.

Pathologic and molecular analyses revealed that the Hodgkin cells contained

Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete

remission after MTX withdrawal, chemotherapy, and radiation. To the best of

my knowledge, this is the sixth report of Hodgkin lymphoma in patients with

juvenile idiopathic arthritis receiving low dose MTX therapy.

Clinical and Laboratory Observations

Journal of Pediatric Hematology/Oncology. 28(9):622-624, September 2006.

Takeyama, Junji MD, PhD *; Sato, Atsushi MD, PhD +; Nakano, Kyoko MD +;

Abukawa, Daiki MD, PhD ++; Ichinohazama, Ryo MD, PhD ; Imaizumi, Masue

MD, PhD +

© 2006 Lippincott & Wilkins, Inc.

________________________________________________________________________

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[Guest guest]

My understanding is that this doctor reports this is the 6th case

that he has seen of Epstein-Barr Virus associated hodgkin lymphoma

with the likely result being contributed to low dose mtx use.

This is a risk factor for low dose methotrexate use.

(drea 11 systemic jra/gerd)

>

> Does this mean that the MTX caused the lymphoma or helped it.

>

> Veri

>

>

> Epstein-Barr Virus Associated Hodgkin Lymphoma in a

9-Year-Old Receiving Long-Term MTX for JIA

>

>

> Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Girl

> Receiving Long-Term Methotrexate Therapy for Juvenile Idiopathic

Arthritis.

> http://www.jpho-online.com/pt/re/jpho/abstract.00043426-200609000-

00013.htm;jsessionid=FrzVv4qp8GYypDJhPVNG0J8GQZ6Tvw1JB66tKspnflzq950G

p1Dy!-1455700262!-949856145!8091!-1

>

> Abstract:

> We describe a case of Hodgkin lymphoma developing in a 9-year-old

girl with

> polyarticular, rheumatoid factor-positive juvenile idiopathic

arthritis

> treated with methotrexate (MTX), prednisone, and naproxen for 5

years.

> Pathologic and molecular analyses revealed that the Hodgkin cells

contained

> Epstein-Barr virus and the viral DNA was monoclonal. She achieved

complete

> remission after MTX withdrawal, chemotherapy, and radiation. To

the best of

> my knowledge, this is the sixth report of Hodgkin lymphoma in

patients with

> juvenile idiopathic arthritis receiving low dose MTX therapy.

>

> Clinical and Laboratory Observations

> Journal of Pediatric Hematology/Oncology. 28(9):622-624, September

2006.

> Takeyama, Junji MD, PhD *; Sato, Atsushi MD, PhD +; Nakano, Kyoko

MD +;

> Abukawa, Daiki MD, PhD ++; Ichinohazama, Ryo MD, PhD ;

Imaizumi, Masue

> MD, PhD +

>

> © 2006 Lippincott & Wilkins, Inc.

>

>

>

>

_____________________________________________________________________

___

> Check out the new AOL. Most comprehensive set of free safety and

security tools, free access to millions of high-quality videos from

across the web, free AOL Mail and more.

>

>

>