Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Receiving Long-Term MTX for JIA

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Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Girl

Receiving Long-Term Methotrexate Therapy for Juvenile Idiopathic Arthritis.

http://www.jpho-online.com/pt/re/jpho/abstract.00043426-200609000-00013.htm;jses\

sionid=FrzVv4qp8GYypDJhPVNG0J8GQZ6Tvw1JB66tKspnflzq950Gp1Dy!-1455700262!-9498561\

45!8091!-1

Abstract:

We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with

polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis

treated with methotrexate (MTX), prednisone, and naproxen for 5 years.

Pathologic and molecular analyses revealed that the Hodgkin cells contained

Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete

remission after MTX withdrawal, chemotherapy, and radiation. To the best of

my knowledge, this is the sixth report of Hodgkin lymphoma in patients with

juvenile idiopathic arthritis receiving low dose MTX therapy.

Clinical and Laboratory Observations

Journal of Pediatric Hematology/Oncology. 28(9):622-624, September 2006.

Takeyama, Junji MD, PhD *; Sato, Atsushi MD, PhD +; Nakano, Kyoko MD +;

Abukawa, Daiki MD, PhD ++; Ichinohazama, Ryo MD, PhD ; Imaizumi, Masue

MD, PhD +

© 2006 Lippincott & Wilkins, Inc.