Dacryocytes - Teardrop shaped cells

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dacryocytes

http://www.copewithcytokines.de/cope.cgi?key=dacryocytes

Called also teardrop cells or tear drop poikilocytes. This cell type occurs

as a result of erythrocyte fragmentation.

These cells are seen in patients with various forms of anaemia (Dash et al,

1988; Farolino et al, 1986).

Bunyaratvej et al (1985) have reported reduced numbers of normally shaped

erythrocytes in patients with beta-thalassemia/HbE disease, which is reduced

further by splenectomy, larger splenic sizes, and increasing anemia. The

numbers of dacryocytes depends on the splenic status. Larger splenic size is

associated with an increased number of dacryocytes, whereas splenectomy is

associated with a noticeable reduction in their numbers.

Kawahara et al (1998) have found these cells in the blood of a patient with

hemolytic anemia. These cells are an initial manifestation of abnormal

copper metabolism associated with 's disease.

These cell types have been observed also in the blood of llamas with

experimentally-induced iron deficiency anemia (Morin et al, 1993).

Pothier et al (1987) have observed a high number of dacryocytes in the

peripheral blood of a patient with congenital dyserythropoietic anaemia.

Oren et al (2001) have observed these cells in autoimmune hemolytic anemia

occurring with myelodysplastic syndrome.

Atkinson et al (1987) have observed numerous dacryocytes in a patient with

blood type A and acute myelomonocytic leukemia.

Taswell et al (1977) have described numerous dacryocytes in the peripheral

blood smear of an apparently healthy individual with McLeod phenotype blood,

in a male patient with type II chronic granulomatous disease who had a

shortened 51Cr red blood cell survival time, and in a minor population of

the red blood cells of his carrier mother.

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Teardrop-shaped red cells in autoimmune hemolytic anemia.

Am J Hematol. 1986 Apr;21(4):415-8.

Farolino DL, Rustagi PK, Currie MS, Doeblin TD, Logue GL.

The presence of teardrop-shaped red cells in peripheral blood has

traditionally been felt to reflect altered marrow architecture, namely

myelofibrosis. We evaluated two patients with splenomegaly, moderately

severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody,

and bone marrow erythroid hyperplasia without myelofibrosis. A striking

predominance of teardrop-shaped red cells was noted upon examination of

their blood films. Removal of a spleen containing extramedullary

hematopoiesis in one and resolution of splenomegaly in the other were

accompanied by disappearance of these cells. Our observations support a role

for the spleen and for extramedullary hematopoiesis in the pathogenesis of

this distinctive red cell morphologic abnormality.

PMID: 3953560 [PubMed - indexed for MEDLINE]

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Teardrop cells (dacrocytes)

http://www.wadsworth.org/chemheme/heme/microscope/teardrop.htm

Teardrop shaped red blood cells are found in myelofibrosis and other

myeloproliferative disorders, pernicious anemia, thalassemia, myeloid

metaplasia, and some hemolytic anemias.

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