Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome.

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Elevated cerebrospinal fluid levels of substance P in patients with the

fibromyalgia syndrome. *

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..

Department of Medicine, University of Texas Health Science Center, San

78284-7874.

OBJECTIVE. To measure, and seek clinical correlates with, levels of

substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome

(FMS) patients. METHODS. CSF from 32 FMS patients and 30 normal control

subjects was tested for SP by radioimmunoassay. Clinical measures included

tender point examination and standardized questionnaires. RESULTS. CSF SP

levels were 3-fold higher in FMS patients than in normal controls (P < 0.001),

but they correlated only weakly with tenderness found on examination.

CONCLUSION. SP is significantly elevated in FMS CSF, but other abnormalities

must exist in FMS to more fully explain the symptoms.

PMID: 7526868 [PubMed - indexed for MEDLINE]

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