Re: Rosetta FW: Juvenile rheumatoid arthritis affected sibpairs

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I call her ped and she wants me to take her to the urgent care after i get off work so say some prayer and hope for the best. i just know in my gut something is going on with her .

thank you

Rosetta

Juvenile rheumatoid arthritis affected sibpairsJuvenile rheumatoid arthritis affected sibpairs: Extent of clinicalphenotype concordanceArthritis & Rheumatism Volume 50, Issue 6 , Pages 1928 - 1934Copyright © 2004 by the American College of Rheumatologyhttp://www3. interscience. wiley.com/

cgi-bin/abstract /109061840/ ABSTRACTAbstractObjectiveTo investigate the clinical phenotypes and demographic characteristicsof 183 affected sibling pairs (ASPs) with juvenile rheumatoid arthritis(JRA) and to determine whether there are differences between theclinical phenotypes of the ASP cohort compared with patients withsporadic disease and whether there is greater sharing of specificclinical features within versus between sibpairs.MethodsDetails of the JRA Affected Sibpair Registry operations have beendescribed previously. The frequencies of phenotypes in the 2 cohortswere tabulated, summary statistics were determined, and comparisons weremade by chi-square test or t-test. Sibling risk, sibling risk ratios(s), and odds ratios were calculated to assess familial aggregation ofseveral different clinical manifestations.ResultsThe most common onset type among the 164

nontwin ASPs was pauciarticular(65% overall). Fifty-three percent of the ASPs were concordant forpauciarticular- onset JRA; 19% were concordant for a polyarticulardisease onset. Among subjects with polyarticular- onset disease,significantly more joints were involved at onset in simplex patientsthan in ASPs. The difference in age at JRA onset within sibpairs(sibling 1 versus sibling 2) was not significantly different. ASPsdeveloped disease at a mean real-time difference of 5.1 years apart.Familial aggregation was found for tenosynovitis (s 29.5), leukocytosis(s 25), rheumatoid factor (s 11.0), anemia (s 1.7), and antinuclearantibodies (s 1.3).ConclusionThis study confirms the findings of earlier studies showing that a highproportion of ASPs overall show concordance of disease-onset type,except for the subset of patients with systemic disease, and thatnontwin ASPs do not develop disease at

the same point in real time.We conclude that JRA and its clinical manifestations do not differsubstantially between ASPs and the simplex population. The exception isthe number of affected joints at JRA onset among patients withpolyarticular- onset disease. Familial aggregation of clinical featuresamong ASPs adds strong evidence for a genetic background in thisdisease.Marta B. Moroldo *, Minakshi Chaudhari, Edith Shear, D. , N. Glass, H. GianniniCincinnati Children's Hospital Medical Center, and University ofCincinnati, Cincinnati, Ohioemail: Marta B. Moroldo (marta.moroldo@ cchmc.org)*Correspondence to Marta B. Moroldo, Division of Rheumatology,Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue,Cincinnati, OH

45229-3039Funded by:National Institute of Arthritis and Musculoskeletal and Skin Diseases;Grant Number: N01-AR-42218, P60-AR-47784, P30-AR-47363