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XOMA 052: potential to improve treatment of a wide variety of inflammatory diseases

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XOMA to Present Data Of Phase 1 Type 2 Diabetes Study

www.rttnews.com/Content/BreakingNews.aspx?Node=B1 & Id=654991%20 & Category=Breaking\

%20News

7/15/2008 3:16 PM ET (RTTNews) - Tuesday, biopharmaceutical company XOMA

Ltd. said it would present results from two ongoing Phase 1 studies of XOMA

052 in Type 2 diabetes examining the safety and pharmacokinetics at the

annual meeting of European Association for Study of Diabetes.

XOMA 052 is a monoclonal antibody with the potential to improve treatment of

patients with a wide variety of inflammatory diseases.

The Berkeley, California-based company said Phase 1 studies would also

examine certain markers of activity such as hemoglobin A1c and C-reactive

protein of XOMA 052 and would enroll up to 72 Type 2 diabetes patients in

total.

Based on the Phase 1 Type 2 diabetes studies, XOMA plans to initiate

clinical studies of XOMA 052 in rheumatoid arthritis, acute gout, and

systemic juvenile idiopathic arthritis in 2008.

The company said that either of the trials did not indicate any serious

drug-related adverse events and that XOMA 052 was consistent with the human

antibody with a terminal half-life of 15-21 days. The company said this drug

profile, when combined with XOMA 052's high binding affinity of 300

femtomolar, could support potential dosing of once per month or longer in

Type 2 diabetes patients.

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