A multicenter study of patients with adult-onset Still’s disease compared with systemic juvenile idiopathic arthritis

[Guest guest]

ORIGINAL ARTICLE

A multicenter study of patients with adult-onset Still’s disease compared

with systemic juvenile idiopathic arthritis

http://www.springerlink.com/content/f13rr652622750p0/

CLINICAL RHEUMATOLOGY Volume 25, Number 5, 639-644, DOI:

10.1007/s10067-005-0138-5

Abstract

Adult-onset Still’s disease (AOSD) has often been regarded as the adult

spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study

aims to compare the clinical and laboratory features, the disease course and

the response to treatment in patients having AOSD with those having sJIA.

Retrospective review of all available data that were filled out by adult and

paediatric rheumatologists from six centers using a standard data extraction

form was performed. A total of 95 patients with AOSD and 25 patients with

sJIA were recruited for the study.

The frequency of fever, rash, myalgia, weight loss and sore throat was

higher in patients with AOSD. The pattern of joint involvement differed

slightly.

Laboratory findings were similar in both groups, except that liver

dysfunction and neutrophilia were more common among adults.

A multiphasic pattern dominated the childhood cases, whereas the most

frequent course was a chronic one in adults.

Corticosteroids and methotrexate were the most commonly employed therapy;

however, chloroquine was another popular therapy in the adult group.

We showed a difference in the rate of clinical and laboratory features

between patients with AOSD and those with sJIA.

AOSD and sJIA may still be the same disease, and children may simply be

reacting differently as the result of the first encounter of the putative

antigens with the immune system.

Buy Online Access to this Article

Individual Article (Electronic Only) USD 34.00