Wasabi nose: an underreported complication of cyclophosphamide infusions

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CASE BASED REVIEW

Wasabi nose: an underreported complication of cyclophosphamide infusions

http://www.springerlink.com/content/j27k027380713070/

CLINICAL RHEUMATOLOGY DOI: 10.1007/s10067-011-1728-z

Abstract

Wasabi nose, a term used to describe the nasopharyngeal discomfort

experienced during cyclophosphamide infusions, is a rare phenomenon,

previously described in case reports of adult oncology patients typically

receiving high-dose chemotherapy regimens. The underlying mechanism by which

this phenomenon occurs is unknown.

We report four cases of children with rheumatic diseases afflicted by

profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide

infusions.

We additionally review the literature regarding potential medical management

of these complications and describe our experience using these

interventions.

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