Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 Mike i will look for my old info slips from 2002 when the pegintron 1st came out and we will see what schearing reccomended at that time ,i printed out those studies you posted , i figgure i will take em to live hcv group on the 11 and let those guys and gals ponder Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 , I'd be interesteded in what they have to say. Just so you know it's all the studies I looked at not just those I shared. The higher the weight based riba dose the higher the SVR improvement especially for geno 1. While adverse events go up SVR goes up a greater percent than adverse events so it looks like a good trade off if you can take the dose like you did. In one wacky study they got a 90% SVR in geno 1 with double the normal riba dose. Highest doses I heard of. Everyone in the study was on various blood boosters and 20% still needed transfusions and hospitilisation. They damn near killed em with anemia on average doses of about 2,400 ranging from 1,600 - 3,200. But almost all of em made it through the study and SVRed. Dose was serum level based not weight based. Some can't take the high dose. If you can't you just can't take it but I'd say that's why we pay for monthly blood work and the only way to tell is to try it. The Itallians did a study and found spaghetti sauce (natural antioxidant) improves anemia significantly. People who take antioxidents typically have about 20% fewer chemo (mostly riba) reductions. So good diet and supplementation can help you stay on high doses. How you did it on beer and no food but TV dinners is another miracle. Your my miracle buddy. The riba don't kill em but it slows viral reproduction and like you mentioned the buggs have to be killed ASAP or else mutate to a resistant strain. Slowing reproduction gives you a chance for the INF to kill em before they mutate. When the new riba (virinamide?) comes out they will probably be uping the doses and effeciency testing it from scratch. With INF they pretty much tested the max effeciency but never did with riba cause of the bad sides. They tested it up to the level the sides freaked em out and never even got to the maximum effective dose which is unknown. I think SVR will go up on this new riba with higher riba dosses and fewer dose reductions cause it is not as toxic to the blood cells. It may be a long time for the new wonder drugs to hit the street but look for the new riba to boost overall SVR 5%-10% and give people like Michele who can't take much regular riba a good shot. That ought to happen in two years or less if you get in a study. Mike > > Mike i will look for my old info slips from 2002 when the pegintron 1st came out and we will see what schearing reccomended at that time ,i printed out those studies you posted , i figgure i will take em to live hcv group on the 11 and let those guys and gals ponder > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 Mike i just found the 1998 slip for the non peg inf and the riba dose is less then < 75 kg 800mg _ 75 kg + 1200mg so i guess its the same also their is a mention of an additional 24 weeks of tx on relaps after 48 weeks of tx but it also states and i was warned no safty data after 48 weeks .But you know i take the Dorris Day approach KAY SA RA SA RA what ever will be will be . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 Mike , oh yea i will let ya know what they think on the studies group the 11 jan come on down or up i mean Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 , I got the 36 weeks minimum after first no HCV pcr from a recent conference on relapsers and hard to treat. The guy who said it is like the grand puba of hard to treat. That's probably not in the product info but I think it is the current best practice for hard to treat. Like you he says retreat ASAP and as long as it responds. Mike > > Mike i just found the 1998 slip for the non peg inf and the riba dose is less then < 75 kg 800mg _ 75 kg + 1200mg so i guess its the same also their is a mention of an additional 24 weeks of tx on relaps after 48 weeks of tx but it also states and i was warned no safty data after 48 weeks .But you know i take the Dorris Day approach KAY SA RA SA RA what ever will be will be . > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2006 Report Share Posted January 8, 2006 Mike ,you dont want to start from 0 point ya gotta keep em on the run if they pop up 6 ,8 months of svr and your safe but until i would keep a close eye on it ..Me and doc used to joke about me getting tested every 2,3,4,weeks said ins comp is going to put a contract on you that pcr costs 450 to 650 a pop depending which test is used .In that 6 months i got 6 tests more in the beginning at 4 months i was feeling confident did five first 4 months then skiped 5 and did 6 ,8 ,10 ,12 after 12 i did and do every 6 but i dont really keep a close watch any more it will just hit me and i test . Quote Link to comment Share on other sites More sharing options...
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