Re: Improving the Odds

January 8, 2006

Read closely , viral kinetics and study Mike ,that study is ok but ya

have to read that stuff really close and pick it appart ,we used to do these

studies at work with animals and its hard for someone who hasent been around

this game to seperate the wording and get to the real meat ,its seems valid for

how the study was done .But it was not a real world study there are alot of

other variables they forgot about . They say low base line viral ct ,what was

their low baseline 1 million per cc/ml 500,000 per ,hi platelet count give me a

number alot of those studies are so vague. In general the study is probably

valid for that criteria and group but in the real world this virus and many

viruses are constently re schuffling the genetic deck ,i had 1b but also many

many varients of 1b some strong ,some week thats why i started with 750,000

copies per cc/ml and 4 months later had 69,000 copies per cc/ml this 69 ,000 was

of a slightley differnt make up or gena type still 1b but a

sub type of 1b . Thats one of natures tricks genetic diversity, and viruses

like this have extreme divirsity that 69, 000 was beginning to learn how to out

smart the inf and or riba either by random luck [re suffeling genitics randomly

, genetic divirsity] or by good ol learning, thease things learn how to out

smart the meds ,you know if something is trying to get the combination to this

virus it knows and will take counter mesures by re schuffeling its genetics at

the attack point where the meds hit the virus. Viruses like this go through so

many generations it expressed as an exponent its like time T = g generations

and over weeks months years it was always expressed as an exponet . This is 1

reason why you gotta get this the 1st time before it gets a good tast of the

meds and starts its counter mesures or by random luck genitic diversity once it

finds that combo the meds are locked out. Some people are unlucky and just by

chance they have some subtypes that allready have a

lock out on meds .Thats why you see some people get an inital drop but on their

next pcr the virus is on its way up ,the meds killed the ones that hadent

changed but the ones thad had changed locked out the meds .Genetic divirsity,

lock out, and the virus can go about its mary way and mutiply back up .And then

you have the multi tx ers from my observations after 2nd falure this virus gets

its thing togther and locks out meds even if its only a fraction of a fraction

of the virus that has mutated its gonna be right back in the game. If your

resistant to inf 1a your resistant to inf 1b alot of docs havent figured this

out yet and torture their patents with another worthless tx .One reason infergen

works is its a synthetic inf with a differnt structure and the virus has never

seen this so in most cases it works, of course this gives many one more shot but

as usually the meds have to be prescribed correctly and for the right length of

time but too many docs have little understanding

of this ,Michele had svr snached right from her hands ,thats why i say as long

as you have insurance have that pcr done after tx stops 2nd week 1st month ect.

That way if you convert to pos you can get back on tx right away with out much

ground lost, hell whats another4 , 6 months after a year. 72 weeks is almost a

guarentee 1 shot then you know if it does not work no meds of this generation

are gonna work. Course if ida converted pos at end of 18 months my plan was to

do 4 month of hi dose infergen like i said when i saw my 4 month pcr i had

straped in for 2 yrs . I knew that 69,000 could have meant a major problem thats

when i droped my ph to 4.5 and they took their good ol time leaving 4 months

but they left with 1 month to spare i was just about ready to pull the infergen

but at month 6 i hit 11,000 and month 8 neg so i stayed the course with the

pegintron even after the converson to neg .Me and doc kicked around the infergen

thing but we agried if its working lets leave well

enough alone ,doc said it will be your luck you have spun off a random sub type

immune to infergen and you will shoot back up to a million ,and i shook my head

and said that would be my luck ,leave well enough alone. I always thought all

that weight loss and staying on the 180 lb dose factored in some where. Maybe

for your last month or two see if doc will give you ,as you put it an off the

richter scale dose of riba if your blood can take it .I told you i did some dose

reductions with the riba sometimes for a week or two ,it was not getting my

blood it was kicking my ass but i alaways did my full shot of peg and took my

extra 20 mics and injected at end of week . All in all it was a lovely vaccation

, it really wasent that bad you kinda get used to it ,i did have a few days

where i thought i was gonna drop dead but then i thought i couldnt be that

luckey ,it was that riba kicking my ass and i had to cut back for a spell but

allways went back up after a week or two .I dont even

remember the 18 months now its like it never happined. Like i said it was never

that bad and i even worked many days .

January 8, 2006