cryoglobulinaemia -- macroglobulinaemia in a patient with chronic hepatitis C.

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A case of progression from type II cryoglobulinaemia to Waldenstrom's

macroglobulinaemia in a patient with chronic hepatitis C.

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Clin Exp Med. 2005; 5(1):40-2 (ISSN: 1591-8890)

Neri S; Pulvirenti D; Mauceri B; Ignaccolo L; Azzolina R

Department of Internal Medicine and Systemic Diseases, University of

Catania, Edificio 29, I piano, Via S. Sofia 86, I-95123 Catania, Italy.

sergio.neri4@...

Hepatitis C infection is associated with B-cell lymphoproliferative

disorders, including mixed cryoglobulinaemia and B-cell lymphoma. A direct

pathogenetic role of this infection in lymphomagenesis has been suggested

but the molecular basis for viral induced B-cell proliferation is still

unknown. We report an unusual case of a patient affected by chronic

hepatitis C who presented severe type II cryoglobulinaemia and

subsequently lymphoplasmacytoid lymphoma consistent with Waldenstrom's

macroglobulinaemia and type I cryoglobulinaemia. In this patient antiviral

treatment induced beneficial effects

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~I will say of the L-rd, He is my refuge andmy

fortress: my G-d; in Him will I trust.Psalm 91;2~~~~~~~~~~~~~~~~~~~~~~~

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