Hepatitis C pharmacogenetics: State of the art in 2010.

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Hepatology. 2011 Jan;53(1):336-345. doi: 10.1002/hep.24052.

Hepatitis C pharmacogenetics: State of the art in 2010.

Afdhal NH, McHutchison JG, Zeuzem S, Mangia A, Pawlotsky JM, Murray JS, Shianna

KV, Tanaka Y, DL, Booth DR, Goldstein DB; for the Pharmacogenetics and

Hepatitis C Meeting Participants.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical

Center and Harvard Medical School, Boston, MA. nafdhal@....

Abstract

In 2009, a correlated set of polymorphisms in the region of the interleukin-28B

(IL28B) gene were associated with clearance of genotype 1 hepatitis C virus

(HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same

polymorphisms were subsequently associated with spontaneous clearance of HCV in

untreated patients. The link between IL28B genotype and HCV clearance may impact

decisions regarding initiation of current therapy, the design and interpretation

of clinical studies, the economics of treatment, and the process of regulatory

approval for new anti-HCV therapeutic agents. (Hepatology 2011).

American Association for the Study of Liver Diseases.

PMID: 21254181 [PubMed - as supplied by publisher]