Guest guest Posted February 4, 2011 Report Share Posted February 4, 2011 http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04589.x/abstract;jse\ ssionid=61F42763C7410A20D37A4AC8320593E2.d03t02?systemMessage=Due+to+scheduled+m\ aintenance%2C+access+to+Wiley+Online+Library+will+be+disrupted+on+Saturday%2C+5t\ h+Feb+between+10%3A00-12%3A00+GMT Meta-analysis: the impact of diabetes mellitus on the immunological response to hepatitis B virus vaccine in dialysis patients F. Fabrizi1, V. Dixit2, P. 2, P. Messa1Article first published online: 1 FEB 2011 DOI: 10.1111/j.1365-2036.2011.04589.x © 2011 Blackwell Publishing Ltd Issue Alimentary Pharmacology & Therapeutics Early View (Articles online in advance of print) Summary Background  Patients on maintenance dialysis typically show a suboptimal immune response to hepatitis B virus vaccine compared with the non-uraemic population. A variety of inherited or acquired factors have been implicated in this diminished response. It is well known that patients with diabetes mellitus have a compromised immune system, and diabetic nephropathy is an important cause of chronic kidney disease. However, the impact of diabetes mellitus on the immune response to HBV vaccine in patients receiving long-term dialysis remains unclear. Aim  To evaluate the influence of diabetes mellitus on the immune response to HBV vaccine in dialysis population by performing a systematic review of the literature with a meta-analysis of clinical studies. Methods  We used the random effects model of DerSimonian and Laird with heterogeneity and sensitivity analyses. The end-point of interest was the rate of patients showing seroprotective antibody against hepatitis B surface antigen at completion of vaccine schedule in the diabetic vs. the nondiabetic dialysis individuals. Results  We identified 12 studies involving 1002 unique patients on long-term dialysis. Aggregation of study results showed a significant decrease in response rates among the diabetic vs. the nondiabetic patients [pooled odds ratio = 0.52 (95% CI 0.38–0.71)]. The P-value was 0.29 for our test of study heterogeneity. Stratified analysis in various subgroups of interest did not meaningfully change our results. Conclusions  Our meta-analysis showed a clear association between diabetes mellitus and impaired response to hepatitis B virus vaccine in individuals on long-term dialysis. Such a relationship is biologically plausible. Vaccination schedules with adapted vaccine doses and frequent serum testing for loss of immunity against hepatitis B virus should be considered in patients on maintenance dialysis with diabetes mellitus. Quote Link to comment Share on other sites More sharing options...
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