Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon

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Journal of Viral Hepatitis 15 (4) , 314–321 doi:10.1111/j.1365-2893.2007.00936.x

Abstract

Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon

vs interferon

C. Yurdaydýn1,21Gastroenterology Department, University of Ankara Medical

School, Ankara, Turkey2Hepatology Institute, University of Ankara, Ankara,

Turkey, H. Bozkaya11Gastroenterology Department, University of Ankara Medical

School, Ankara, Turkey, F. O. Önder11Gastroenterology Department, University of

Ankara Medical School, Ankara, Turkey, H. Þentürk33Department of

Gastroenterology, Cerrahpaþa Medical Faculty, University of Istanbul, Istanbul,

Turkey, H. Karaaslan11Gastroenterology Department, University of Ankara Medical

School, Ankara, Turkey, M. Akdoðan33Department of Gastroenterology, Cerrahpaþa

Medical Faculty, University of Istanbul, Istanbul, Turkey, H.

Çetinkaya11Gastroenterology Department, University of Ankara Medical School,

Ankara, Turkey, E. Erden44Pathology Department, University of Ankara Medical

School, Ankara, Turkey, Ö. Erkan-Esin22Hepatology Institute, University of

Ankara, Ankara, Turkey, K. Yalçýn55Department of Gastroenterology, Dicle

University, Diyarbakýr, Turkey, A. M. Bozdayý1,21Gastroenterology Department,

University of Ankara Medical School, Ankara, Turkey2Hepatology Institute,

University of Ankara, Ankara, Turkey, R. F. Schinazi66Department of Pediatrics,

Emory University School of Medicine and Veterans Affairs Medical Center,

Atlanta, GA, USA, J. L. Gerin77Division of Molecular Virology and Immunology,

town University Medical Center, Rockville, MD, USA, Ö.

Uzunalimoðlu22Hepatology Institute, University of Ankara, Ankara, Turkey and A.

Özden11Gastroenterology Department, University of Ankara Medical School, Ankara,

Turkey1Gastroenterology Department, University of Ankara Medical School, Ankara,

Turkey;2Hepatology Institute, University of Ankara, Ankara, Turkey; 3Department

of Gastroenterology, Cerrahpaþa Medical Faculty, University of Istanbul,

Istanbul, Turkey; 4Pathology Department, University of Ankara Medical School,

Ankara, Turkey; 5Department of Gastroenterology, Dicle University, Diyarbakýr,

Turkey; 6Department of Pediatrics, Emory University School of Medicine and

Veterans Affairs Medical Center, Atlanta, GA, USA; and 7Division of Molecular

Virology and Immunology, town University Medical Center, Rockville, MD,

USA

Cihan Yurdaydýn, Gastroenterology Section, University of Ankara Medical School,

Cebeci Týp Fakültesi Hastanesi Dikimevi, 06100 Ankara, Turkey. E-mail:

cihan.yurdaydin@...

Abstract

Summary. Chronic delta hepatitis is the most severe form of chronic viral

hepatitis for which interferon (IFN) is the only available treatment. In 39

patients (25 were treatment-naïve, 14 had previously used IFN), efficacy of

1-year treatment with IFN (9 MU, t.i.w.) or lamivudine (LAM; 100 mg, q.d.) alone

was compared with IFN and LAM combination (2 months of LAM to be followed by

combination treatment). IFN monotherapy was given only to treatment-naïve

patients. In both treatment-naïve and previous IFN users, end of treatment

virological and biochemical responses were similar with IFN–LAM combination and

superior to LAM monotherapy (P < 0.05). Improvement in liver histology occurred

more often with IFN ± LAM than with LAM alone (P < 0.05). In treatment-naïve

patients, combination treatment was not superior to IFN monotherapy. After

treatment discontinuation, virological and biochemical response rates decreased

in LAM and IFN combination and IFN monotherapy. On treatment virological

response at month 6 of treatment predicted sustained virological response. The

results of this study suggest that addition of LAM to IFN for the treatment of

delta hepatitis is of no additional value and that both treatment modalities are

superior to LAM monotherapy.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2893.2007.00936.x

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