Re: Re: treatment time shorter study

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.Shortcuts.hostSpaceId = " 97546168 " ; Shorter Hepatitis C

treatment more successful and cost-effective

Washington, Jan 3: A recent study has revealed that Hepatitis C (HCV), when

treated with peginterferon and ribavirin, for shorter durations, can yield

success rates similar to those from longer treatment lengths, with cost-savings

and lower risk of serious side effects.

Peginterferon are natural proteins produced by the cells of the immune system

and ribavirin is an anti-viral drug active against a number of DNA and RNA

virus.

The study led by Alessandra Mangia of Italy's Istituto di Ricovero e Cura a

Carattere Scientifico, Casa Sollievo Della Sofferenza, in San Giovanni Rotondo

conducted a randomised controlled trial of patients with HCV genotype 1.

The study included 696 patients, 237 of whom received standard HCV and 459 were

treated for 24, 48, or 72 weeks.

The findings revealed that about 49 percent of patients receiving variable

treatment based on detectable viral levels showed a persistent viral response,

as 45 percent of patients in the standard group.

The patients who showed a viral response at week 4 were treated by a 24-week

therapy and for those who did not show a response until week 12, 72 weeks of

treatment was required for an approximately similar cure rate.

" In conclusion, variable treatment duration ensures a sustained viral response

rate similar to that of standard treatment duration, with potential significant

reduction in cost and side effects. " the authors report.

Researchers in Norway also conducted similar trials on 428 patients with HCV

genotype 2 or 3 to measure the success rate of 14 weeks of treatment with

peginterferon plus ribavirin.

Patients who achieved a viral response after 4 weeks were randomly assigned to

complete either 14 or 24 total weeks of treatment.

The study revealed that 81 percent of patients in the 14-week treatment group

achieved a constant viral response, with 86 percent still cured at 24-weeks

post-treatment.

About 91 percent of patients in the 24-week treatment group achieved a sustained

viral response, with 93 percent still cured at 24-weeks post-treatment.

" We cannot formally claim that 14 weeks treatment is non-inferior to 24 weeks

treatment, " the authors conclude.

" However, the sustained viral response rate after 14 weeks treatment is high,

and although longer treatment may give a slightly better sustained viral

response rate, we believe considerable economical savings, good response to

re-treatment and less side effects make it rational to treat patients with

genotype 2 or 3 and rapid viral response for only 14 weeks, " the authors said.

The findings appear in the January issue of Hepatology.

http://www.newkeral a.com/one. php?action= fullnews & id=8991

[

yurgingerbreadwoman <no_reply > wrote: I'm not feeling

too well tonight but in response to the weight thing I

do believe there is a definate correlation between weight gain and

liver problems. Many people are now being told they have fatty liver

and one of them is my younger daughter. She started having problems

with bowel function and was gaining a lot of weight. She has always

had the bowel problems but the weight gain was occurring after she

moved away from home. When she went to the doctor they did an

ultrasound and a scan and found her to have fatty liver. She has been

trying to eat better but with a hectic schedule she has a tendency to

eat out too much.

> >

> > ok they say my liver is huge!! was uroligist remarks on ct scan.but

> > nothing showed other then enlarged liver,ultra sound was negative as

> > well,cbc and rbc,afp. all normal.still have svr.any ideas y the huge

> > liver or is that part of hcv? urine was clean as well.

> >

>

>

>

>

>

>

> Tim Parsons

>

> knoxville,tn 37931

>

> 865-588-2465 x107 work

>

>

> www.knoxville1.com

>

>

>

> ---------------------------------

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