Effectiveness of a Chinese hamster ovary cell derived hepatitis B vaccine in Chinese Rural Communities.

April 11, 2011

Vaccine. 2011 Mar 29. [Epub ahead of print]

Effectiveness of a Chinese hamster ovary cell derived hepatitis B vaccine in

Chinese Rural Communities.

Zhang Y, Ma JC, Qi SX, Wang F, Zhao C, Bi SL.

Chinese Center for Disease Control and Prevention, Institute for Viral Disease

Control and Prevention, Beijing 100052, PR China.

Abstract

OBJECTIVE: To evaluate the effectiveness of a Chinese hamster ovary cell derived

hepatitis B vaccine in a country community in Hebei Province, PR China.

METHOD: A cross-sectional investigation was carried out in 4 of 7 randomly

selected country communities in Zhengding County in 2005. All of the children

who were born between 1997 and 1999 were selected as study objects. Their serum

samples were taken to test for HBV markers, and HBsAg prevalence was compared to

that of the same age group before hepatitis B vaccination in 1983. In addition,

for HBsAg positive children, their mothers were visited and tested for serum HBV

markers, in order to distinguish maternal HBV transmissions.

RESULTS: Among the 2205 children of the selected birth cohort, 1696 (76.9%) were

visited. The prevalence of HBsAg was 0.53%, and by comparing to that of before

hepatitis B vaccination, the effectiveness was 95.3%, similar to that of yeast

derived hepatitis B vaccines. Among 7 mothers of HBsAg positive children, 5 were

HBsAg positive, indicating maternal HBV transmissions; and although one mother

was HBsAg negative, her kid was not vaccinated, which indicates a horizontal

transmission. As for the other kid, he was adopted and the HBV infection status

of his birth mother was unknown.

CONCLUSION: The effectiveness of the CHO derived hepatitis B vaccine is

comparable to yeast derived ones, and after the hepatitis B vaccination maternal

transmission is the most important route of spreading HBV.

PMID: 21457729 [PubMed - as supplied by publisher]

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