There were no differences in serum HBV DNA level between HBeAg-positive and HBeAg-negative chronic hepatitis B with same liver histological necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned by the same hepatic parenchyma

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http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01444.x/abstract

There were no differences in serum HBV DNA level between HBeAg-positive and

HBeAg-negative chronic hepatitis B with same liver histological

necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned

by the same hepatic parenchyma cell volume

W.-M. Ke1, S.-B. Xie1, X.-J. Li1, S.-Q. Zhang1, J. Lai1, Y.-N. Ye1, Z.-L. Gao1,

P.-J. Chen2Article first published online: 24 MAR 2011

DOI: 10.1111/j.1365-2893.2011.01444.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Articles online in advance of print)

Summary. 

Hepatitis B virus (HBV) DNA levels and liver histological necroinflammation

grades are correlated with the antiviral efficacy. It is necessary to clarify

the relationship between HBV replication levels apportioned by the same hepatic

parenchyma cell volume and severity of liver histological necroinflammation

grades in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative chronic

hepatitis B. The serum HBV DNA levels apportioned by the same hepatic parenchyma

cell volume were compared between HBeAg-positive and HBeAg-negative chronic

hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3

and 4, respectively. There were no differences in the serum HBV DNA levels

between HBeAg-positive and HBeAg-negative chronic hepatitis B as well as among

liver histological necroinflammation grades 1, 2, 3 and 4. However, there were

differences in the serum HBV DNA levels apportioned by the same hepatic

parenchyma cell volume among liver histological necroinflammation grades 1, 2, 3

and 4 in both HBeAg-positive and HBeAg-negative chronic hepatitis B,

respectively. There were no differences in HBV DNA levels with the same liver

histological necroinflammation grade activated by HBV wild-type and variant

strains. After the differences in hepatic parenchyma cell volume for HBV

replication of the same liver histological necroinflammation grade accompanied

by different hepatic fibrosis stages were adjusted, the serum HBV DNA level

apportioned by the same hepatic parenchyma cell volume was correlated with the

severity of liver histological necroinflammation grade.