HEPATITIS C RECURRENCE AFTER LIVER TRANSPLANTATION: HAS THE HLA MISMATCHING AT INDIVIDUAL LOCI A ROLE?

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http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06772.x/abstract

HEPATITIS C RECURRENCE AFTER LIVER TRANSPLANTATION: HAS THE HLA MISMATCHING AT

INDIVIDUAL LOCI A ROLE?

Maxime AUDET MD, Tullio PIARDI MD, Murat CAG MD, Francis NAVARRO MD, PhD, Sara

ORNIS MD, Jacques CINQUALBRE MD, PhD, Philippe WOLF MD, PhD, Fabrizio PANARO MD,

PhD

DOI: 10.1111/j.1440-1746.2011.06772.x

© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell

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Journal of Gastroenterology and Hepatology

Accepted Article (Accepted, unedited articles published online for future

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Author Information

Centre de Chirurgie Viscérale et de Transplantation, Hôpital de Hautepierre,

Université Louis Pasteur, 67000-Strasbourg, France

*Correspondence: Fabrizio PANARO MD, PhD,

*Correspondence: Fabrizio PANARO, MD, PhD Dept. of Surgery, Multivisceral

Transplant Centre Montpellier University Hospital School of Medicine 80, Avenue

Augustin FLICHE 34295, Montpellier, France Phone: +33-677659806 Fax:

+33-467337652 E-mail:f-panaro@...

This is an Accepted Article that has been peer-reviewed and approved for

publication in the Journal of Gastroenterology and Hepatology, but has yet to

undergo copy-editing and proof correction. Please cite this article as an

“Accepted Article”; doi: 10.1111/j.1440-1746.2011.06772.x

Publication History

Accepted manuscript online: 18 MAY 2011 06:58AM EST

Received date: 12-Jan-2011 , Accepted date: 2-May-2011

ABSTRACT

Background/Aim: The objective of this 11-year cohort retrospective study

conducted in adult patients with chronic HCV who underwent LT was to identify

whether HLA mismatching is associated with the recurrence of HCV and with the

time to recurrence of HCV. Methods: Among the 181 patients (74% men; mean age:

54 years, range 25-71) who underwent a LT between 1995 and 2006 in the study

center, 163 had relevant data in their medical chart documenting HCV recurrence,

and 107 (65.64%) reported a histological evidence of HCV recurrence. Results:

Survival was 78% at 5 years. There was no significant relationship between the

total score of HLA-mismatches and the recurrence of HCV. Similarly, there was no

significant relationship between the total score of HLA mismatches and the time

to recurrence of HCV. For the analyses at each individual locus, a significant

relationship between the individual scores of HLA-mismatches and the recurrence

of HCV were observed. Out of the 40 patients who experienced a rejection, the

rate of recurrence was not different according to the severity of the rejection

(75% mild, 64% moderate and 64% for severe rejection). Conclusions: In

conclusion, this large study did not demonstrate any relationship between the

total score of HLA mistaches and HCV-recurrence. Contrarily a significant

relationship between the individual scores of HLA mismatches (HLA-A3, HLA-B35,

HLA-DR3, HLA-DR7, HLA-DQ2, HLA-DQ2-0) and the recurrence of HCV were observed.