Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in

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Hepatology Research

OnlineEarly Articles

To cite this article: Nobukazu Ishizaka, Yuko Ishizaka, Seki, Ryozo

Nagai, Minoru Yamakado, Kazuhiko Koike (2008)

Association between hepatitis B/C viral infection, chronic kidney disease and

insulin resistance in individuals undergoing general health screening

doi:10.1111/j.1872-034X.2008.00334.x

Abstract

Original Article

Association between hepatitis B/C viral infection, chronic kidney disease and

insulin resistance in individuals undergoing general health screening

Nobukazu Ishizaka,1Departments of 1Cardiovascular Medicine,Dr Nobukazu Ishizaka,

Department of Cardiovascular Medicine, University of Tokyo Graduate School of

Medicine, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan. Email:

nobuishizka-tky@... Yuko Ishizaka,22Center for Multiphasic Health Testing

and Services, Mitsui Memorial Hospital, Tokyo, Japan Seki,33Nephrology,

University of Tokyo Graduate School of Medicine, and Ryozo Nagai,1Departments of

1Cardiovascular Medicine, Minoru Yamakado22Center for Multiphasic Health Testing

and Services, Mitsui Memorial Hospital, Tokyo, Japan and Kazuhiko

Koike44Infectious Diseases andDepartments of 1Cardiovascular Medicine,

4Infectious Diseases and 3Nephrology, University of Tokyo Graduate School of

Medicine, and 2Center for Multiphasic Health Testing and Services, Mitsui

Memorial Hospital, Tokyo, Japan

Dr Nobukazu Ishizaka, Department of Cardiovascular Medicine, University of Tokyo

Graduate School of Medicine, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan.

Email: nobuishizka-tky@...

Abstract

Aim: Previous studies have shown that hepatitis B virus (HBV) and hepatitis C

virus (HCV) infection may be associated with glomerulonephritis.

Methods: In the current study, we investigated the possible association between

HBV/HCV infection, estimated GFR (eGFR) and albuminuria by analyzing

cross-sectional data from individuals undergoing general health screening.

Results: Of 12 535 individuals enrolled, 130 (1.0%) and 72 (0.6%) tested

positive for HBV surface antigen and HCV core antigen, respectively. In

comparison with hepatitis-negative individuals, the prevalence of low eGFR and

albuminuria was significantly greater in individuals with HCV infection, but not

in those with HBV infection. Logistic regression analysis adjusted for age, sex,

systolic blood pressure and fasting plasma glucose showed that HCV infection was

positively associated with low eGFR (odds ratio 1.63 [95% CI 0.95–2.80, P =

0.077] ) and with albuminuria (odds ratio 2.00 [95% CI 1.06–3.76, P = 0.003] ).

By contrast, prevalence of neither low eGFR nor albuminuria was greater in

individuals with HBV infection than in hepatitis-negative subjects. Further

adjustment for either HOMA-IR or serum alanine aminotransferase levels abolished

the statistical significance in the association between HCV infection and

albuminuria.

Conclusion: Our data suggest that although both HCV and HBV infection are

associated with increased insulin resistance, the different viruses may have

different impacts on chronic kidney disease among Japanese individuals

undergoing general health screening.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1872-034X.2008.00334.x

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