Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes

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Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes

Liver International, 09/02/2011

Connell LE et al. – The findings provide understanding of the association

between maternal hepatitis B or C carrier status and perinatal outcomes. Infants

born to women with hepatitis C infection appear to be at risk for poor birth

outcomes, including preterm birth,low birth weight(LBW) and congenital anomaly.

Methods• All Florida births from 1998 to 2007 using birth certificate records

linked to hospital discharge data were analysed.

Results•Study sample consisted of 1670369 records.

• Human immunodeficiency virus co-infection and all forms of substance abuse

were more frequent in mothers with hepatitis B and C infection.

• After using multivariable modelling to adjust for important

socio-demographical variables and obstetric complications, women with hepatitis

C infection were more likely to have infants born preterm [odds ratio (OR),

1.40; 95% confidence intervals (CI), 1.15-1.72], with LBW (OR, 1.39; 95% CI,

1.11-1.74) and congenital anomaly (OR, 1.55; 95% CI, 1.14-2.11).

• In addition, women with hepatitis B infection were less likely to have

infants born SGA (OR, 0.79; 95% CI, 0.66-0.95).

http://www.ingentaconnect.com/content/mksg/liv/2011/00000031/00000008/art00014

Liver International, Volume 31, Number 8

Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes

Authors: Connell, E.1; Salihu, Hamisu M.; Salemi, L.1; August, Euna

M.2; Weldeselasse, Hanna1; Mbah, Alfred K.1

Source: Liver International, Volume 31, Number 8, 1 September 2011 , pp.

1163-1170(8)

Publisher: Wiley-Blackwell

Abstract:

Background and aims: To examine the association between maternal hepatitis B and

C mono- and co-infections with singleton pregnancy outcomes in the state of

Florida.

Methods: We analysed all Florida births from 1998 to 2007 using birth

certificate records linked to hospital discharge data. The main outcomes of

interest were selected pregnancy outcomes including preterm birth, low birth

weight (LBW), small for gestational age (SGA), fetal distress, neonatal jaundice

and congenital anomaly.

Results: The study sample consisted of 1 670 369 records. Human

immunodeficiency virus co-infection and all forms of substance abuse were more

frequent in mothers with hepatitis B and C infection. After using multivariable

modelling to adjust for important socio-demographical variables and obstetric

complications, women with hepatitis C infection were more likely to have infants

born preterm [odds ratio (OR), 1.40; 95% confidence intervals (CI), 1.15-1.72],

with LBW (OR, 1.39; 95% CI, 1.11-1.74) and congenital anomaly (OR, 1.55; 95% CI,

1.14-2.11). In addition, women with hepatitis B infection were less likely to

have infants born SGA (OR, 0.79; 95% CI, 0.66-0.95).

Conclusions: Our findings provide further understanding of the association

between maternal hepatitis B or C carrier status and perinatal outcomes. Infants

born to women with hepatitis C infection appear to be at risk for poor birth

outcomes, including preterm birth, LBW and congenital anomaly.

Document Type: Research article

DOI: 10.1111/j.1478-3231.2011.02556.x

Affiliations:1: Department of Epidemiology and Biostatistics, College of Public

Health, University of South Florida, Tampa, FL, USA 2: Department of Community

and Family Health, College of Public Health, University of South Florida, Tampa,

FL, USA

Publication date: 2011-09-01