Maternal Hepatitis B and Hepatitis C r Status and Perinatal Outcomes

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http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02556.x/abstract

Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes

E. Connell1, Hamisu M. Salihu1,2, L. Salemi1, Euna M. August3, Hanna

Weldeselasse1, Alfred K. Mbah1

Article first published online: 7 JUN 2011

DOI: 10.1111/j.1478-3231.2011.02556.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Volume 31, Issue 8, pages 1163–1170, September 2011

Abstract

Background and aims: To examine the association between maternal hepatitis B and

C mono- and co-infections with singleton pregnancy outcomes in the state of

Florida.

Methods: We analysed all Florida births from 1998 to 2007 using birth

certificate records linked to hospital discharge data. The main outcomes of

interest were selected pregnancy outcomes including preterm birth, low birth

weight (LBW), small for gestational age (SGA), fetal distress, neonatal jaundice

and congenital anomaly.

Results: The study sample consisted of 1 670 369 records. Human immunodeficiency

virus co-infection and all forms of substance abuse were more frequent in

mothers with hepatitis B and C infection. After using multivariable modelling to

adjust for important socio-demographical variables and obstetric complications,

women with hepatitis C infection were more likely to have infants born preterm

[odds ratio (OR), 1.40; 95% confidence intervals (CI), 1.15–1.72], with LBW (OR,

1.39; 95% CI, 1.11–1.74) and congenital anomaly (OR, 1.55; 95% CI, 1.14–2.11).

In addition, women with hepatitis B infection were less likely to have infants

born SGA (OR, 0.79; 95% CI, 0.66–0.95).

Conclusions: Our findings provide further understanding of the association

between maternal hepatitis B or C carrier status and perinatal outcomes. Infants

born to women with hepatitis C infection appear to be at risk for poor birth

outcomes, including preterm birth, LBW and congenital anomaly.