The Effect of Vaccinated Children on Increased Hepatitis B Immunization Among High-Risk Adults

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CDC 05-02-08

UNITED STATES: " The Effect of Vaccinated Children on Increased Hepatitis B

Immunization Among High-Risk Adults "

Am Journal of Public Health Vol. 98; No. 5: P. 832-838 (05..08):: Deepika L.

Koya, MD, MSCR; G. Hill, PhD; M. Darden, MD

The authors of the current study sought to assess trends in hepatitis B virus

(HBV) vaccination among high-risk adults and to determine the potential effect

vaccinated adolescents have on these trends as they age.

Using data from the National Health Interview Survey 2000, 2002 and 2004, HBV

vaccination trends were examined among high-risk adults ages 18-49 and in age

subgroups (18-29, 30-39, and 40-49). Temporal differences in vaccination rates

from the 18-29 cohort were investigated via model-based linear contrasts

constructed from a logistic regression model with age and survey year as

predictors.

The study results showed a significant increasing trend in vaccination

prevalence across the three survey years (32.6 percent, 35.3 percent and 41.4

percent; trend test, P=.001). After adjusting for relevant confounders,

respondents ages 18-29 were more likely to be vaccinated against HBV in 2004

than in 2000 (odds ratio=1.73; 95 percent confidence interval=1.14, 2.6); there

was no significant increase in vaccination for the other cohorts.

" A cohort effect, in which successfully vaccinated adolescents have reached

young adulthood, contributes significantly to recent trends showing improved HBV

vaccination among high-risk adults, " the authors concluded.

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