Jump to content
RemedySpot.com

Biology of Immune Responses to Vaccines in Elderly Persons

Rate this topic


Guest guest

Recommended Posts

Guest guest

Clinical Infectious Diseases 2008;46:1078–1084

© 2008 by the Infectious Diseases Society of America. All rights reserved.

1058-4838/2008/4607-0019$15.00

DOI: 10.1086/529197

VACCINES

INVITED ARTICLE

Biology of Immune Responses to Vaccines in Elderly Persons

Birgit Weinberger,

Dietmar Herndler-Brandstetter,

Angelika Schwanninger,

a Weiskopf, and

Beatrix Grubeck-Loebenstein

Immunology Division, Institute for Biomedical Aging Research, Austrian Academy

of Sciences, Innsbruck, Austria

With increasing age, the human immune system undergoes characteristic changes,

termed immunosenescence, which lead to increased incidence and severity of

infectious diseases and to insufficient protection following vaccination.

Functional defects and altered frequencies of innate and adaptive immune cells

impair local responses at the site of vaccine injection, hamper the generation

of primary responses to neoantigens, prevent the effective induction of memory

lymphocytes, and decrease the effect of booster vaccination. As a result,

antibody responses of elderly vaccinees are weaker and decline faster, and

long-term protective effects of vaccination cannot be taken for granted in

elderly persons. Improved vaccination strategies, new adjuvants, and new

vaccines that specifically target the aged immune system will help to overcome

the limitations of immunosenescence and ensure a better protection of the

vulnerable elderly population.

Received 9 October 2007; accepted 3 December 2007; electronically published 29

February 2008.

Reprints or correspondence: Dr. Beatrix Grubeck-Loebenstein, Institute for

Biomedical Aging Research, Rennweg 10, 6020 Innsbruck, Austria

(beatrix.grubeck-loebenstein@...).

Stanley Plotkin, Section Editor

http://www.journals.uchicago.edu/doi/abs/10.1086/529197

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

http://club.live.com/star_shuffle.aspx?icid=starshuffle_wlmailtextlink_jan

Link to comment
Share on other sites

Join the conversation

You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...