Twenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: Final report

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Vaccine. 2008 Sep 30. [Epub ahead of print]

Twenty-two years follow-up of a prospective randomized trial of hepatitis B

vaccines without booster dose in children: Final report.

But DY, Lai CL, Lim WL, Fung J, Wong DK, Yuen MF.

Department of Medicine, The University of Hong Kong, Queen Hospital,

Pokfulam Road, Hong Kong, China.

Long-term immunogenicity and efficacy of HBV vaccination with different regimens

of HBV vaccines (A: 2-dose recombinant vs. B: 3-dose recombinant vs. C: 3-dose

plasma-derived vaccines) without booster dose were examined in 318 Chinese

children. Geometric mean titer (GMTs) of anti-HBs of group A subjects was

significantly lower than that of groups B and C subjects at years 1, 5, 10 and

15. At year 22, the proportion of subjects with anti-HBs>/=10mIU/mL for groups

A, B and C were 35.3%, 76.5% and 52.4%, respectively (p/=1 episodes of

anamnestic response. In conclusion, the 3-dose regimens have a better long-term

immunogenicity. In terms of protection against HBV infection, the 2-dose and

3-dose vaccines had equal efficacies.

PMID: 18835318 [PubMed - as supplied by publisher]