Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B

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http://www.springerlink.com/content/461w70p2581w3t04/

Journal Digestive Diseases and Sciences

Publisher Springer Netherlands

ISSN 0163-2116 (Print) 1573-2568 (Online)

Category Original Article

DOI 10.1007/s10620-008-0541-2

Subject Collection Medicine

Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in

Chronic Hepatitis B

Do Young Kim1, 3, 4, Seung Up Kim1, 4, Sang Hoon Ahn1, 3, 4, Jun Yong Park1, 3,

4, Jung Min Lee1, 4, Young Nyun Park2, 4, Ki Tae Yoon1, 4, Yong Han Paik1, 3, 4,

Kwan Sik Lee1, 3, 4, Chae Yoon Chon1, 3, 4 and Kwang-Hyub Han1, 3, 4

(1) Department of Internal Medicine, Yonsei University College of Medicine, 250

Seongsanno, Seodaemun-gu, Seoul, 120-752, South Korea

(2) Department of Pathology, Yonsei University College of Medicine, Seoul,

South Korea

(3) Institute of Gastroenterology, Yonsei University College of Medicine,

Seoul, South Korea

(4) Liver Cirrhosis Clinical Research Center, Seoul, South Korea

Received: 17 June 2008 Accepted: 11 September 2008 Published online: 13

November 2008

Abstract Background It is difficult to differentiate early compensated

cirrhosis from chronic hepatitis solely by clinical features. The aim of this

study was to assess the usefulness of liver stiffness measurement (LSM) for

detection of early compensated liver cirrhosis in chronic hepatitis B (CHB).

Methods Ninety-one consecutive CHB patients who underwent liver biopsy (LB) and

LSM were recruited. All patients did not fulfill the clinical criteria for

cirrhosis. The cutoff of LSM for cirrhosis was 10.3 kPa. Results All patients

were divided into either group A (cirrhosis) or group B (CHB) according to LB

result. The median LSM values of groups A and B were 11.8 and 7.6 kPa,

respectively (P < 0.001). The sensitivity, specificity, positive predictive

value, and negative predictive value of LSM in predicting cirrhosis were 0.59,

0.78, 0.68, and 0.72, respectively. The area under the receiver operating

characteristics curve (AUROC) of LSM was 0.803, whereas the AUROCs of aspartate

to alanine aminotransferase ratio (AAR) and aspartate aminotransferase to

platelet ratio index (APRI) were 0.488 and 0.723, respectively. Conclusions LSM

showed an acceptable diagnostic accuracy for detecting early compensated

cirrhosis in CHB.

Do Young Kim and Seung Up Kim have contributed equally to this work.

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Kwang-Hyub Han

Email: gihankhys@...