Correlates of poor perceived health among individuals living with HIV and HBV chronic infections: a longitudinal assessment

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Correlates of poor perceived health among individuals living with HIV and HBV

chronic infections: a longitudinal assessment

Authors: Fabienne Marcellinabc; Karine Lacombedef; Lionel Fugonabc; Jean-Michel

Molinag; Philippe Bonnardefh; Miailhesi; Caroline Lascoux-Combeg;

Perrine Rouxabc; P. riabc; Pierre-Marie Girarddef; Bruno Spireabc

Abstract

Chronic hepatitis B virus (HBV) infection affects up to 14% of people living

with HIV and AIDS (PLWHA) and is associated with a higher risk of non-AIDS

death. While great advances have been made in the therapeutic management of

co-infection with HIV and HBV, nothing is known about perceived health in people

living with HIV and HBV. This study aimed at characterizing individuals with

poor perceived overall health among 308 HIV-HBV co-infected individuals enrolled

between May 2002 and May 2003 in a three-year French cohort. A binary score for

perceived overall health (good vs. poor) was calculated from individuals'

responses to the COOP-WONCA charts at cohort enrolment and at quarterly visits

throughout the follow-up. Mixed models were used to explore factors associated

with this score. At enrolment, 190 individuals (62%) reported poor overall

health. In the multivariate analysis, low CD4 percentage, co-infection with

hepatitis C or D viruses, HIV diagnosis before 1996 and HBeAg positivity were

independently associated with poor perceived overall health. Poor perceived

health concerns a considerable portion of individuals living with HIV and HBV.

Individuals with wild-type HBV and multiple hepatitis infection require better

clinical management. Further research is needed for hepatitis D virus infection,

for which treatment options are currently very limited.