The influence of hepatitis C virus–human immunodeficiency virus co-infection on the appearance of li

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Digestive and Liver Disease

Volume 40, Issue 6, June 2008, Pages 460-467

The influence of hepatitis C virus–human immunodeficiency virus co-infection on

the appearance of liver enzyme elevation in people on high activity

antiretroviral treatment

European Journal of Internal Medicine, Volume 16, Issue 6, October 2005, Pages

405-407

J. Olalla, R. Rubio, J.R. Costa, A. del Palacio, L. Hidalgo, F. Poveda, J.J.

García-Alegría

Abstract

Background

Liver enzyme elevation (LEE) as a consequence of HAART is a problem among

patients with HIV–HCV co-infection.

Methods

In this retrospective study, 145 patients with HIV who were on HAART and who

developed LEE grades 3 and 4 of the World Health Organization (WHO) were

followed up. Basal ALT, alcohol consumption, and HCV and HBV co-infection were

recorded. Comparisons were made between patients with and without HCV

co-infection.

Results

Three patients without co-infection presented LEE grade 3 versus 38 with

co-infection (104 episodes). An increase in basal ALT (RR: 1.01) and HCV

co-infection (RR: 6.6) were the variables associated with LEE grade 3. The

number of days that HAART had to be withdrawn due to LEE was 58.15 and 4.85 in

subjects with and without co-infection, respectively (p = 0.024).

Conclusion

Patients with HCV–HIV co-infection have more episodes of LEE and must go longer

without HAART than people without co-infection.

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Prevalence of diabetes mellitus and dyslipidemia among ...

Journal of Infection

Prevalence of diabetes mellitus and dyslipidemia among antiretroviral naïve

patients co-infected with hepatitis C virus (HCV) and HIV-1 compared to patients

without co-infection

Journal of Infection, Volume 50, Issue 4, May 2005, Pages 331-337

Fehmida Visnegarwala, Li Chen, Subha Raghavan, Ellen Tedaldi

Abstract

Objective. An increased prevalence of type 2 diabetes mellitus (DM) has been

associated with HCV in the non-HIV infected populations. To describe a similar

association among HIV subjects, and explore the biological mechanisms.

Methods. In a cross-sectional analysis, we compared the prevalence of DM (using

American Diabetes Association criteria) and insulin resistance (HOMA IR) and

dyslipidemia among ARV naïve patients with HIV and HIV/HCV infected patients

enrolled in CPCRA FIRST (058) and the Metabolic Substudy (061).

Results. Among 1389 enrolled in the FIRST study and had HCV serology, the

prevalence of diabetes was higher (5.9%) among HCV/HIV as compared to 3.3% among

those with HIV alone (p=0.04). Among 417 enrolled in the metabolic substudy, 88

(21%) had HIV/HCV co-infection. As in the main study, the prevalence of DM was

higher in HIV/HCV group (9 vs. 3%, p=0.03). The HIV/HCV infected were

significantly older (43 vs. 37 years), non-white (83 vs. 70%), with a history of

IDU (55 vs. 3%), had higher AST (61 vs. 39 U/l), ALT (55 vs. 43 U/l,) and lower

cholesterol levels (3.97 vs. 4.25 mmol/l). By multivariate analysis among

subjects

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