Antiviral therapy using lamivudine and thymosin alpha1 for hepatocellular carcin

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Hepatogastroenterology. 2006 Mar-Apr;53(68):249-52.

Antiviral therapy using lamivudine and thymosin alpha1 for hepatocellular

carcinoma coexisting with chronic hepatitis B infection.

Shuqun C, Mengchao W, Han C, Feng S, Jiahe Y, Wenming C, Zhengfeng Y,

Yuxiang Z, Peijun W.

Eastern Hepatobiliary Surgery Institute, Eastern Hepatobiliary Surgery

Hospital The Second Military Medical University, Shanghai 200438, P. R.

China. chengshuqun@...

BACKGROUND/AIMS: To observe the recurrence and prognosis of patients with

hepatocellular carcinoma (HCC) coexisting with chronic hepatitis B infection

with active virus replication after receiving antivirus therapy using

lamivudine and thymosin alpha1 postoperatively. METHODOLOGY: From Jan. 2000

to Dec. 2002, 33 patients with HCC coexisting chronic hepatitis B infection

with active virus replication were prospectively divided into two groups:

control group (n= 17) received hepatectomy only, treatment group (n= 16)

received hepatectomy and lamivudine plus thymosin alpha1 therapy

postoperatively. The suppression of HBV-DNA, HBeAg seroconverted rate,

recurrent tumor rate and the median survival for the two groups were

observed and calculated. RESULTS: For the treatment group and control group,

the one-year HBV-DNA suppression rate was 100% vs. 6% (p=0.0016); HBeAg

seroconverted rate was 62.5% vs. 5.9% (p=0.0157); The median recurrent time

was 7.0 vs. 5.0 months (p=0.0052); The median survival period was 10.0 vs.

7.0 months (p=0.10053), respectively. CONCLUSIONS: Antivirus therapy using

lamivudine and thymosin alpha1 postoperatively may suppress the HBV

reaction, delay the recurrent time and prolong the survival for HCC patients

coexisting with chronic HBV infection with active virus replication.

PMID: 16608033 [PubMed - in process]

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