Role of hepatitis B virus, hepatitis D virus and other determinants on suppression of hepatitis C viraemia in HIV infected patients with chronic HCV infection: A longitudinal evaluation

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Role of hepatitis B virus, hepatitis D virus and other determinants on

suppression of hepatitis C viraemia in HIV infected patients with chronic HCV

infection: A longitudinal evaluation

Authors: Giorgio Antonucci a; Francesco Vairo a; Fabio Iacomi a; Ubaldo Visco

Comandini a; carmela Solmone b; Pierluca Piselli c; Evangelo Boumis a;

Francesco Nicola Lauria a; ria Capobianchi b; Giuseppe Ippolito d;

Vincenzo Puro c

Affiliations: a From the Clinical Department of Infectious Disease,

b Laboratory of Virology,

c Department of Epidemiology,

d Scientific Direction, National Institute for Infectious Diseases, L.

Spallanzani, Rome, Italy

DOI: 10.1080/00365540802275846

Publication Frequency: 12 issues per year

Published in: Scandinavian Journal of Infectious Diseases

First Published on: 23 July 2008

Subject: Infectious Diseases;

Abstract

The role of hepatitis B virus (HBV) or hepatitis D virus (HDV) coinfections as

determinants of hepatitis C virus (HCV) suppression in the setting of HIV-HCV

coinfection are poorly understood. Our aim was to assess whether HCV viral

replication may be affected by HBV or HDV coinfection in the setting of

immunodeficiency driven by HIV.Among the 138 enrolled patients 28(20.3%) tested

HCV RNA negative and 110 (79.7%) tested HCV RNA negative. The HCV RNA negative

patients showed an higher rate of HBsAg positivity compared with those tested

HCVRNA positive [12/28 (42.9%) and 5/110 (4.6%), respectively]. Patients with

HCV-HBV-HDV coinfection had the highest chance of having an undetectable HCV RNA

(adjusted odds ratio (AOR): 92.0, 95% confidence interval (CI) 5.7-1483.5, p