Disinhibition and SSRIs and venlafaxine

[Guest guest]

Sick...these guys talk about this stuff like they're discussing football

stats...sick...

http://www.dr-bob.org/tips/split/Disinhibition-and-SSRIs-an.html

Disinhibition and SSRIs and venlafaxine

Dr. Bob'sPsychopharmacology Tips

Disinhibition and SSRIs and venlafaxine

Date: Wed, 17 Apr 1996 17:03:39 -0700 (PDT)

From: " W. Steinhoff" <ksteinho@...>

Subject: Disinhibition from fluoxetine or venlafaxine

On Wed, 17 Apr 1996, Fumio Inoue wrote:

Anyone heard of fluoxetine induced (or exacerbated) kleptomania?

Not in adults, but in pre-pubertal children. In fact, fluoxetine clearly causes a dose related dis-inhibition of behavior in pre-pubertal children. I have seen this as well with venlafaxine.

You might look at:

Riddle MA et al.

Behavioral side effects of fluoxetine in children and adolescents.

Journal of Child Adolescent Psychopharmacology 1 (3):193-198,

1990-91.

Date: Wed, 17 Apr 1996 20:13:54 -0500

From: gsdavids@... ( son)

Subject: Disinhibition and fluoxetine

I have heard anecdotes of this on the public radio in Canada, in

one of those "what the doctors don't tell you about Prozac" programs. The

cases I heard sound like most of the other horror stories one hears about

Prozac -- it was given for the worng reasons or to the wrong patient, or was badly

supervised, or, most commonly, the doctor didn't listen to the patient, but

insisted on the patient doing what the doctor told him or her to do.

On the other hand, I have seen several cases of kleptomania

stopping on Prozac in my own practice. The effect seems to be somehow

connected to ADHD and occurs with other SSRIs too. It

is such an amazing phenomenon that it has

prompted me to enquire more closely from my patients what effects the

antidepressant has had on any habits they didn't care to tell me about when

they first came in. A couple have now mentioned that their compulsive

shoplifting has stopped, which was a big relief to them.

I have seen a couple of people who developed a kind of moral

lassitude on Prozac or other SSRIs. I think they had passive-aggressive

tendencies that were kept in check by anxiety or depression -- feeling

better allowed them to express tendencies that were always there.

Date: Sun, 21 Apr 1996 09:53:35 -0400 (EDT)

From: Alan Eppel <eppela@...>

Subject: Disinhibition from fluoxetine

I have one patient, a woman in her 30s, with bulimia anorexia, who while on fluoxetine (Prozac) shoplifted several identical pieces of (uneeded) underwear.

Date: Tue, 9 Jul 1996 19:10:18 -0700

From: " W. Steinhoff" <ksteinho@...>

Subject: Disinhibition from venlafaxine

Theoretically the noradrenergic effect of venlafaxine should be helpful for attention.

The problem is that the noradrenergic effect doesn't kick in until higher

doses. In prepubertal children this frequently has already led to a

serotonergic disinhibition (as occurs with fluoxetine). These kids are very

embarrassed and ashamed of all the things they did when they were "under the

influence" of the serotonin agent. The disinhibition also can look a lot

like ADHD which muddies the waters.

Date: Wed, 22 May 1996 06:22:24 -0700

From: tgarton@... (Theresa Garton )

Subject: Disinhibition from SSRIs

I attended an excellent program this past weekend on child and adolescent psychopharmacology. The speaker was Popper, MD. In discussing SSRIs, he indicated that he had personally discontinued their use in children due to the frequency he had encountered a "frontal syndrome" characterized by either

lack of concern

or disinhibition (this despite the prominent Zoloft display in the lobby). He suggested addition of bupropion or some "other noradrenergic agent" to counteract this effect in adults.

Date: Mon, 15 Jul 1996 16:33:15 -0700

From: " W. Steinhoff" <ksteinho@...>

Subject: Disinhibition and SSRIs and venlafaxine

"Serotenergic disinhibition" looks like hypomania, but is primarily in the

social arena. I have seen it in at least 4 prepubertal children, 1 with

venlafaxine, 3 with Prozac (fluoxetine). It is dose related. Turn it up, they become

party animals (talking out in class, doing silly things, not thinking about

social consequences, etc.), turn it down, they can't believe how they

acted -- scary. It may be related to why SSRIs do well with social phobia.

This topic is indexed under the following subjects:

Antidepressants, new (bupropion, mirtazapine, nefazodone, venlafaxine)

Antidepressants, selective serotonin reuptake inhibitors

Impulse-control problems

Match:

all terms

any term

[

Psychopharmacology Tips |

Interpsych |

Mental Health Links

]

Dr. Bob is Hsiung, MD,

dr-bob@...

URL: http://www.dr-bob.org/tips/split/Disinhibition-and-SSRIs-an.html

Original tips copyright 1994-97 original authors.

Web page copyright 1995-97 Hsiung.

[Guest guest]

They should talk to Winona Ryder about her kleptomania and Zoloft use!!!!! LOL