973. Usefulness of Liver Biopsy in Chronic HBV with Normal Transaminases in an European Setting: High prevalence of advanced liver fibrosis and cirrhosis

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973. Usefulness of Liver Biopsy in Chronic HBV with Normal Transaminases in an

European Setting: High prevalence of advanced liver fibrosis and cirrhosis

T. Goebel; U. Heinzel-Pleines; C. Poremba; S. E. Baldus; M. Herwig; M.

Molderings; D. Haussinger; A. Erhardt

Introduction:

In chronic HBV-infection indication for antiviral treatment depends on

ALT-levels, liver histology and viral load. In general, antiviral treatment is

initiated if transaminases are elevated and/or significant liver fibrosis or

inflammation is detected in liver histology. The present study aimed at

investigating the prevalence of advanced fibrosis in patients with normal ALT

and near normal (2ULN

(n=130)

Significant liver fibrosis [™F3]

16/38 (42%)

45/84 (54%)

82/130 (63%)

Liver cirrhosis

9/38 (24%)

21/84 (25%)

28/130 (22%)

Significant inflammation [™G2]

7/27 (26%)

34/66 (52%)

71/104 (68%)

HBeAg-positivity

17/38 (45%)

24/84 (29%)

61/130 (47%)

Male/Female [%]

53/47

73/27

79/21

HBV-DNA [mean IU/ml]

1782101

788698

1869311