Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection

January 5, 2011

Chemistry and Materials Science European Journal of Nutrition

DOI: 10.1007/s00394-010-0156-1Online Firstâ„¢

Original Contribution

Vitamins B status and antioxidative defense in patients with chronic hepatitis B

or hepatitis C virus infection

Chun-che Lin, Wen-hu Liu, Zhi-hong Wang and Mei-chin Yin

Abstract

Background & Aims

The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon

B vitamins status and antioxidative defense in infected patients was examined.

Methods

Dietary record and blood levels of B vitamins and oxidative stressâ€“associated

biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV

patients.

Results

HBV-infected patients had significantly higher levels of total cholesterol, free

fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients

had significantly higher Ishak inflammation score and lactate dehydrogenase

activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC)

vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins

B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation

coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2

and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs

Ishak inflammation score in HCV patients were <âˆ’0.5. HBV-infected patients had

significantly higher oxidized glutathione level and lower glutathione peroxidase

activity (p < 0.05), but HCV patients had significantly lower superoxide

dismutase and catalase activities (p < 0.05).

Conclusion

HBV or HCV infection enhanced oxidative stress and lowered B vitamins in

circulation. In order to avoid other healthy risk, nutrition status should be

monitored and limitation or supplementation of certain nutrients might be

helpful for HBV- or HCV-infected patients.

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