Uncovering Glucose Abnormalities in People With Hepatitis C Infection: Should Oral Glucose Tolerance Test Become a Standard of Care?

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Uncovering Glucose Abnormalities in People With Hepatitis C Infection: Should

Oral Glucose Tolerance Test Become a Standard of Care?

Authors: Aytaman, Ayse1; McFarlane, Samy I.2

Source: The American Journal of Gastroenterology, Volume 103, Number 8, August

2008 , pp. 1941-1943(3)

Publisher: Blackwell Publishing

Abstract:

Hepatitis C and type 2 diabetes mellitus (DM) are two rising epidemics with

significant impact on each other. Hepatitis C-infected patients have a higher

incidence of type 2 diabetes, and diabetic patients have a high prevalence of

hepatitis C. There is mounting evidence that glucose abnormalities have a

negative impact on the disease progression as well as antiviral therapy

outcomes. Utilization of oral glucose tolerance testing has the potential to

uncover previously undetected DM as well as impaired glucose tolerance or

prediabetes in patients with chronic hepatitis C (CHC). Early detection of

diabetes and prediabetes with oral glucose tolerance testing in CHC patients can

lead to interventions, with significant positive impact on disease progression

and antiviral therapy outcomes.

(Am J Gastroenterol 2008;103:1941-1943)

Document Type: Research article

DOI: 10.1111/j.1572-0241.2008.02007.x

Affiliations: 1: Division of Gastroenterology, VA New York Harbor Healthcare

System 2: SUNY Health Science Center at Brooklyn, Brooklyn, New York