Interference of replication between hepatitis B and C viruses in patients infected with HIV

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J Med Virol. 2011 Jul;83(7):1159-64. doi: 10.1002/jmv.22102.

Interference of replication between hepatitis B and C viruses in patients

infected with HIV.

Yang RR, Gui X, Chen XY, Zhu Y.

Source

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan,

China.

Abstract

The clinical and cellular interactions between hepatitis B virus (HBV) and

hepatitis C virus (HCV) were investigated in patients co-infected with the human

immunodeficiency virus (HIV). One hundred ninety-nine patients followed for 6

years were evaluated to compare the level of HBV DNA and HCV RNA in patients

co-infected with HIV and HBV, and patients co-infected with HIV, HBV, and HCV. A

full-length HBV genome and HCV JFH1 RNA were co-transfected into HuH-7.5.1 cells

in vitro to examine the impact of co-infection and dependence on the HBV PreC

mutant for replication interference. Before 2',3'-dideoxy-3'-thiacytidine

(3TC)-based antiretroviral therapy (ART) was initiated, HBV DNA was found in

56/123 (45.4%) patients co-infected with HIV and HBV, and in 19/76 (25.0%)

patients co-infected with HIV, HBV, and HCV. After 3TC-based ART was initiated,

detectable HBV DNA decreased to 7/76 (9.2%) in patients co-infected with HIV,

HBV, and HCV, but HCV RNA increased from 43/76 (56.6%) to 60/76 (78.9%)

(P = 0.003). In vitro HBV and HCV co-infection led to decreased replication

of both viruses. The primary factors that influenced the decreased replication

were the order of the HBV and HCV infection and the HBV PreC mutation.

J. Med. Virol. 83:1159-1164, 2011.

© 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21567419 [PubMed - in process]