Adjuvant info: Can vaccines cause immune dysfunction resulting in allergies, asthma and anaphylaxis?

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Sheri Nakken <vaccineinfo@...> wrote: Adjuvant info: Can vaccines cause immune dysfunction resulting in allergies, asthma and anaphylaxis? There is much adjuvant info within all below http://64.41.99.118/vran/vaccines/anaphylaxis/vaccine_ana.htm Can vaccines cause immune dysfunction resulting in allergies, asthma and anaphylaxis? The Institute of Medicine's Immunization Safety Review Committee held

a public meeting in Seattle, Washington on November 12, 2001 to review the "Possible association between multiple immunizations in newborns and infants and immune system dysfunction." The Institute of Medicine Report stated... "The committee looked at five studies examining multiple vaccinations and their potential to cause allergic diseases, which reflect a hypersensitivity of the immune system to relatively harmless agents in the environment, like pollens, dust mites, insect venom, and specific foods. Some, but not all, of these studies suggested that certain vaccines increase the risk of developing allergic disorders. Methodological weaknesses and inconsistent findings among the studies, however, led the committee to conclude that there is inadequate evidence to either accept or reject a causal relationship between multiple immunizations and increased risk of allergic diseases,

particularly asthma." Clearly, the Institute of Medicine has not ruled out the vaccine connection to allergic disease. (top) Anaphylaxis Action's submission to the Institute of Medicine Anaphylaxis Action c/o Rita Hoffman, R. R. #2, Stirling, Ontario, Canada. K0K 3E0 613-478-3236 Email: pancakehillsympatico (DOT) ca November 6, 2001 Immunization Safety Review Committee National Academy of Sciences Institute of Medicine FO 3009 2101 Constitution Avenue NW Washington, D.C. 20418 Re: Epidemic of Children with Anaphylaxis Dear Dr. McCormick, Chair & Committee, Thank you for the opportunity to submit the following information for your review of the possible association between multiple immunizations in newborns and infants and immune system dysfunction. We are writing in particular about the

potentially life threatening allergic response called anaphylaxis. The exact numbers of children affected by anaphylaxis are difficult to pinpoint. A study in Arch Intern Med 2001 Jan 8;161(1):15-2, Anaphylaxis in the United States: an investigation into its epidemiology, concluded with "The occurrence of anaphylaxis in the US is not as rare as is generally believed. On the basis of our figures, the problem of anaphylaxis may, in fact, affect 1.21% (1.9 million) to 15.04% (40.9 million) of the US population." PMID 11146694 In June of this year an article by Associated Press Writer Jim Fitzgerald entitled Peanut Butter Wars Rage in Schools stated "Schools that haven't had a dangerously allergic pupil can expect one soon." And "peanut allergies among schoolchildren were 'barely on the radar' a decade ago, said Dr. Goldman, a New York allergist and Immunologist who specializes in

pediatric cases." "Now I'm seeing a tremendous number of cases," he said. "It seems like the incidence is really increasing. As to why, I don't think anyone in the world could tell you for sure." In Canada, the Anaphylaxis Canada's Summer 2001 newsletter states that "20% of Canadians suffer from some form of allergy and approximately 4% of children and 2% of adults have developed a potentially lethal allergy to food." The cover story in the September 2000 issue of Professionally Speaking, the magazine of the Ontario College of Teachers is "An Abnormal Response to Normal Things." The article begins with "Teachers have to be aware that allergies can kill. A growing number of children are at risk - and a well prepared teacher can make all the difference." The article explains that "About a decade ago, the sudden surge in highly allergic children entering school systems across the province

caught many educators off guard." Why the "surge" in anaphylactic children entering school a decade ago? These children were among the first to receive an additional vaccination, Hib meningitis. Is it possible that the Pertussis and Hib vaccine, both shown below to cause allergic responses, are creating a hypersensitive immune system in some children? Has any study looked into what happens to atopy incidence and IgE levels when 5 vaccines are given concurrently in infants? CAN VACCINES CAUSE FOOD ALLERGIES? JAMA 2001 Apr 4;285(13):1746-8 Detection of peanut allergens in breast milk of lactating women states, "Most individuals who react to peanuts do so on their first known exposure".................and concluded "Peanut protein is secreted into breast milk of lactating women following maternal dietary ingestion. Exposure to peanut protein during breastfeeding is a route of

occult exposure that may result in sensitization of at-risk infants." PMID 11277829 Women have been ingesting peanut protein while breastfeeding for decades. What has changed in the last 15 years to cause infants to develop life-threatening allergies to this legume? One change has been the vaccination schedule. The Int Arch Allergy Immunol 1999 Jul; 119(3):205-11 Pertussis adjuvant prolongs intestinal hypersensitivity concludes: Our findings indicate nanogram quantities of PT (pertussis toxin), when administered with a food protein, result in long-term sensitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens. PMID 10436392 Does this study explain why babies and toddlers react on their first exposure to the peanuts or other antigens? The

babies may have been sensitized by the vaccines to the proteins through breast milk or formula ingested at the time of vaccination. This would also explain why children are anaphylactic to a variety of proteins, such as different tree nuts, peanuts, egg, legumes, milk, seeds, etc., depending on what proteins the mother ate at the time of vaccination. (top) IS THE INTRODUCTION OF THE HIB VACCINE CONNECTED TO THE INCREASE IN FOOD ANAPHYLAXIS IN CHILDREN? Rates of anaphylaxis have increased dramatically since the introduction of the Hib vaccine. Clin Exp Pharmacol Physiol 1979 Mar-Apr;6(2):139-49 Comparison of vaccination of mice and rats with Haemophilus influenzae and Bordetella pertussis as models of atopy, states "The Haemophilus influenzae vaccinated experimental animal provides a model that is possibly more related to human atopy than the Bordetella pertussis vaccinated

animal." PMID 311260 Ann Allergy 1979 Jan;42(1):36-40 states "To determine whether Haemophilus influenzae could be a factor in human atopy its effects were studied on the (para-)Sympathic Cyclic nucleotide-histamine axis in rats. Haemophilus influenzae vaccination induced changes in the cholinergic system compatible with higher cyclic GMP levels and enhanced histamine release. The authors suggest an involvement of the cholinergic system in Haemophilus influenzae vaccination effects. PMID 216288 Agents Actions 1984 Oct;15(3-4):211-5 entitled Bronchial hyper-reactivity to histamine induced by Haemophilus influenzae vaccination states "......This suggests a hyper-reactivity of the parasympathethic, cholinergic pathways as a result of H.influenzae vaccination." PMID 6335351 Eur J. Pharmacol 1980 Apr 4;62(4):261-8 entitled The effects of Haemophilus influenzae vaccination

on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release states "These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. Influenzae vaccination." PMID 6154589 DOES THE PERTUSSIS VACCINE CAUSE ASTHMA, ALLERGIES AND ANAPHYLAXIS? Pediatrics 1988 Jun (81) Supplement - Report on the Task Force on Pertussis and Pertussis Immunization - extract states, For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis. Bull Eur Physiopathol Respir 1987;23 Suppl 10:111s-113s A model for experimental asthma: provocation in guinea-pigs immunized with Bordetella pertussis states, " Guinea-pigs were sensitized with killed Bordetella pertussis..... the presence of the immediate type

of immune response was verified by passive cutaneous anaphylaxis..... B. pertussis not only alters adrenergic function but provocation in B. pertussis-sensitized guinea-pigs seems to be a good model for bronchial asthma. PMID 2889487 Pediatr Res 1987 Sep;22(3):262-7 Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction..........the results of our experiments have established that the disease induced by coimmunizing mice with Ptx and BSA is due to an immediate type hypersensitivity. PMID 3309858 Infect Immun 1987 Apr.;55(4):1004-8 Anaphylaxis or so-called encephalopathy in mice sensitized to an antigen with the aid of pertussigen (pertussis toxin), states, Sensitization of mice with 1mg of bovine serum albumin (BSA) or chicken egg albumin (EA)

..............induced a high degree of anaphylactic sensitivity when the mice were challenged i.v. with 1 mg of antigen 14 days later. PMID 3557617 JAMA 1994 Aug 24-31;272(8):592-3 Pertussis vaccination and asthma: is there a link? A study of 450 children, 11% of the children who had received the pertussis vaccination suffered from asthma, as compared with only 2% of the children who had not been vaccinated. PMID 8057511 Allergy 1983 May;38(4):261-71 The non-specific enhancement of allergy. III. Precipitation of bronchial anaphylactic reactivity in primed rats by injection of alum or B. pertussis vaccine: relation of response capacity to IgE and IgG2a antibody levels. .....These results show that injection of alum or B. pertussis vaccine without antigen can precipitate/enhance anaphylactic response capacity and production of specific and non-specific IgE and IgG2a. PMID 6307077

(top) CAN VACCINE ADJUVANTS CAUSE ALLERGIES AND ANAPHYLAXIS? Requests for information on the types of adjuvants currently used in human vaccines have not been answered to date. We did find that adjuvants are used to create allergic animals for scientific study and also that peanut oil has been used as an adjuvant. Peanut is by far the most common food to cause anaphylaxis in young children. Is peanut oil, or a similar protein or portion of a protein used in human vaccines as an adjuvant or "protein coat" in the Hib vaccine? Aluminum has also been used as an adjuvant and is known to cause allergies according to the studies below. Could the adjuvants used in vaccines over the last 15 years be creating anaphylactic and allergic children? J Allergy Clin Immunol 2001 Apr;107(4):693-702 Murine model of atopic dermatitis associated with food hypersensitivity states, "Female C3H/HeJ mice were

sensitized orally to cow's milk or peanut with a cholera toxin adjuvant and then subjected to low-grade allergen exposure....................An eczematous eruption developed in approximately one third of mice after low-grade exposure to milk or peanut proteins...................This eczematous eruption resembles AD (atopic dermatitis) in human subjects and should provide a useful model for studying immunopathogenic mechanisms of food hypersensitivity in AD." PMID 11295660 Allergy 1980 Jan;35(1):65-71 Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs. Pattern of response in relation to immunization regimen....guinea-pigs sensitized with small amounts of antigen together with alum produced IgE and IgG1 antibodies. PMID 7369497 Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea

pigs to tetanus toxoid. It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases. PMID 707792 Pediatric Allergy Immunol 1994 May;5(2):118-23 Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines. The role of aluminum for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status..................the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response. The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role

of immunization for the development of allergy merits further studies. PMID 808719 Adv Drug Deliv Rev 1998 Jul 6;32(3):155-172 entitled Aluminum compounds as vaccine adjuvants stated, "Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-Cell responses. PMID 10837642 ls of Asthma, Allergy and Immunology, Vol. 85, Number 1, July 2000 article T-cell subsets (Th1 versus Th2) includes Figure 7 on page 15 - "Factors responsible for the imbalance of the Th1/Th2 responses which is partly responsible for the increased prevalence of allergy in Western countries. Risk for atopy - Th2, increased exposure to some allergens and Th2-biasing vaccines (alum as adjuvant)." PMID 10923599 Vaccine 1992;10(10):714-20 Parameters

affecting the immunogenicity of microencapsulated tetanus toxoid states "As expected, incomplete Freund's adjuvant (IFA) proved to be a more potent adjuvant than peanut oil................" PMID 1523881 Can J Comp Med 1985 Apr;49(2):149-51 compared 6 different adjuvants in swine including four mineral oil compounds, one peanut oil compound and aluminum hydroxide. PMID 4016580 C R Acad Sci Hebd ces Acad Sci D 1975 Apr 7;280(13):1629-32 states........ a stable water in oil emulsion can be produced by using metabolizable peanut oil with arlacel. When mycobacteria are added, a potent emulsified oil adjuvant is obtained which increases the immune response to BSA and to influenza vaccine. PMID 811378 (top) ARE MULTIPLE VACCINES CAUSING OUR IMMUNE SYSTEMS TO FAIL? Immunology Today, March 1998, Volume 19, p. 113-116 states, "Modern vaccinations, fear of germs and

obsession with hygiene are depriving the immune system of information input upon which it is dependent. This fails to maintain the correct cytokine balance and fine-tune T-cell regulation, and may lead to increased incidences of allergies and autoimmune diseases." PMID 9540269 From the journal Allergy 1999, 54, 398-399, Multiple Vaccination effects on atopy, "An increase in the incidence of childhood atopic diseases may be expected as a result of concurrent vaccination strategies that induce a Th2-biased immune response. What should be discussed is whether the prize of a reduction of common infectious diseases through a policy of mass vaccination from birth is worth the price of a higher prevalence of atopy." PMID 10371102 Journal of Manipulative and Physiological Therapeutics, Feb. 2000; 23(2):81-90, Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and

allergy-related respiratory symptoms among children and adolescents in the United States, "The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects. The odds of having any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects." PMID 10714532 Thorax 1998 Nov;53(11):927-32 Early childhood infection and atopic disorder, stated "Interpretation of the prediction of atopic disorders by immunisation with whole cell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation. However, plausible immune mechanisms are identifiable for the promotion of atopic disorders by both factors and further investigation of these association is warranted." PMID 10193389 Epidemiology 1997

Nov;8(6):678-80 Is infant immunization a risk factor for childhood asthma or allergy? This study followed 1,265 children born in 1977. The 23 children who received no DPT and polio immunizations had no recorded asthma episodes or consultations for asthma or other allergic illness before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30% consultations for other allergic illness. Similar differences were observed at ages 5 and 16 years. PMID 9345669 Arerugi 2000 Jul;49(7):585-92, The Effect of DPT and BCG vaccinations on atopic disorders findings include, "From these results we conclude that DPT vaccination has some effect in the promotion of atopic disorders......." PMID 10944825 International Archives of Allergy and Immunology 121:1:2000, 2-9, Genetic and environmental factors contributing to the onset of allergic disorders. "The

increasing prevalence of allergy in developed countries suggests that environmental factors acting either before or after birth also contribute to regulate the development of Th2 cells and/or their function. The reduction of infectious diseases in early life due to increasing vaccinations, antimicrobial treatments as well as changed lifestyle are certainly important in influencing the individual outcome in the Th response to ubiquitous allergens. PMID 10686503 In conclusion, living with anaphylaxis is to be continually on guard for minute quantities of everyday food or other substances that may cause death. Keeping anaphylactic children safe involves the whole community including the child, parents, teachers, bus drivers, caregivers, friends and family. It is our hope that the Committee will investigate the questions we have raised and will recommend further investigation into the connection

between vaccines and this most distressing allergic disease called anaphylaxis. Your time is greatly appreciated. Respectfully yours, Rita Hoffman Additional studies linking vaccines to allergic responses: Clinical Immunology 2001 Sep;100(3):355-61 Infection of human B lymphocytes with MMR vaccine induces IgE class switching. Imani F, Kehoe KE. Circulating immunoglobulin E (IgE) is one of the characteristics of human allergic diseases including allergic asthma........ Here, we show that infection of a human IgM(+) B cell line with MMR resulted in the expression of germ line epsilon transcript. In addition, infection of freshly prepared human PBLs with this vaccine resulted in the expression of mature IgE mRNA transcript. Our data suggest that a potential side effect of vaccination with live attenuated viruses may be an increase in the expression of IgE. PMID

11513549 Additional vaccine adjuvant studies using nut oils: Vaccine 1996 Dec;14(17-18):1703-6 Immune responses following cocktails of inactivated measles vaccine and Arachis hypogaea L. (ground nut) or Cocos nucifera L. (coconut) oils adjuvant. Eghafona NO. "The study suggests that the oils under investigation, particularly to GO (ground nut) oil should be considered as an adjuvant with IMV (Inactivated Measles Vaccine) after extensive study in humans; since it stimulated cellular immune response comparable to that of LMV (Live Measles Vaccine). PMID 9032902 Agents Actions 1976 Feb;6(1-3):75-85 Adjuvant disease induced by mycobacteria, determinants of arthritogenicity. Audibert, F, states "Our previous findings showed that the water soluble adjuvant (WSA) of M.smegmatis which could substitute for mycobacterial cells in Freund's complete adjuvant and induce delayed hypersensitivity

was not arthritogenic in the Wistar rat. We have since observed that auto-immune diseases could be elicited by WSA. PMID: 181972 (top) What is being injected into our children? Why can't we find out? What adjuvants are used in the vaccines? An Access to Information request to Health Canada for the 100% composition of vaccines given to infants received the response, "I regret to inform you that the exact composition of these vaccines cannot be disclosed to you as the information is protected under ATIA (Access to Information Act) Section 20(1)(a)(©. This is a mandatory exemption which protects confidential business information." The Act, under Third Party Information, states, 20. (1) Subject to this section, the head of a government institution shall refuse to disclose any record requested under this Act that contains a) trade secrets of a third party; financial,

commercial, scientific or technical information that is confidential information supplied to a government institution by a third party and is treated consistently in a confidential manner by the third party; c) information the disclosure of which could reasonably be expected to result in material financial loss or gain to, or could reasonably be expected to prejudice the competitive position of, a third party; or d) information the disclosure of which could reasonably be expected to interfere with contractual or other negotiations of a third party." Health Canada eventually sent the vaccine product monographs, which list some ingredients of the vaccines but not all. This is an absolute outrage that parents cannot received full disclosure of vaccine ingredients being injected into their children. This is not "informed consent". In Canada numerous health, provincial and federal government

officials, anaphylaxis and allergy organizations have been contacted by Anaphylaxis Action with a plea for further investigation of the anaphylaxis epidemic and it's connection to vaccination. One brave Member of Parliament, then Alliance Health Critic Elley, requested that the issue be brought forward to the Standing Committee on Health. In the meeting on April 6, the day that the item was supposedly on the agenda, the Chair of the Committee said, "and on March 15 Mr. Elley submitted a letter with respect to the ailment noted." Potentially life threatening anaphylaxis is the "ailment noted" and was never discussed. When Anaphylaxis Action tried to get a copy of the minutes of the Sub-Committee for Agenda Planning meetings from April 4 and April 6, 2000 to prove that the issue was on the table that day our Access to Information request was met with "The minutes of in camera Committee meetings are classed

as Secret Records by the National Archives for a period of 30 years." We were also told that "the agendas have not been preserved in electronic form." Health Minister Allan Rock, in response to a plea to investigate the connection between anaphylaxis and vaccines stated in a Jan 2001 letter, "As stated in my previous correspondence, there are many causes of anaphylaxis." The letter concluded with "Severe anaphylaxis happens infrequently (after vaccination) and is rarely fatal." There was no mention of the epidemic of 3-5%, and now reports of up to 8% of children in this country who are anaphylactic. Anaphylaxis was included in the Canadian Paediatric Surveillance Program, as a new study for 2000. The lead investigator has not responded to Anaphylaxis Action's request for further information, but we did learn from IMPACT News Summer 2001 , a "pediatric hospital-based national active

surveillance network for vaccine-associated adverse events, "that there were "more than 700 case reports in a year and a half" of anaphylaxis. Speaking of this high number, the newsletter goes on to say: "A final group of studies focusing on a much higher rate of incidence collects data that will be used to develop educational material or influence future public health decisions." -------------------------------------------------------- Sheri Nakken, former R.N., MA, Hahnemannian Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK Vaccines - http://www.wellwithin1.com/vaccine.htm Vaccine Dangers & Homeopathy Online/email courses