Number of mutations within CTL-defined epitopes of the hepatitis B Virus (HBV) core region is associated with HBV disease progression.

[Guest guest]

J Med Virol. 2011 Dec;83(12):2082-7. doi: 10.1002/jmv.22226.

Number of mutations within CTL-defined epitopes of the hepatitis B Virus (HBV)

core region is associated with HBV disease progression.

Kim D, Lyoo KS, D, Hur W, Hong SW, Sung PS, Yoon SK, Mehta S.

Source

Division of Infectious Diseases, University of California, San Diego, School of

Medicine, La Jolla, California.

Abstract

The virologic determinants of progressive liver disease associated with

hepatitis B virus (HBV) remain unclear. Previous investigations have associated

HBV disease with specific mutations but this association may be confounded by

HBV genotype, HLA haplotype of the infected individual or both. The association

between non-synonymous mutations located within putative cytotoxic T-lymphocyte

directed epitopes (CDE) of the HBV core region and disease states was

investigated. Subjects infected with HBV were enrolled from a clinical cohort in

Seoul, Korea, and HBV core gene sequences were analyzed for mutational patterns

inside and outside of CDE with respect to subject demographics and HBV-related

disease states. No specific mutation or pattern of mutations were associated

with progressive disease states; however, individuals with cirrhosis and

hepatocellular carcinoma had greater numbers of non-synonymous mutations within

CDE when compared to those with chronic HBV infection who were HBeAg positive

(P = 0.007 and 0.026, respectively). In conclusion, this study demonstrates

that HBV disease progression is associated with viral escape mutations that are

a marker of CTL activity. These data suggest that the number of non-synonymous

mutations in the HBV core region may predict HBV disease progression better than

any single mutation or pattern of mutations. J. Med. Virol. 83:2082-2087, 2011.

© 2011 Wiley Periodicals, Inc.

Copyright © 2011 Wiley Periodicals, Inc.

PMID: 22012714 [PubMed - in process]

[Guest guest]

J Med Virol. 2011 Dec;83(12):2082-7. doi: 10.1002/jmv.22226.

Number of mutations within CTL-defined epitopes of the hepatitis B Virus (HBV)

core region is associated with HBV disease progression.

Kim D, Lyoo KS, D, Hur W, Hong SW, Sung PS, Yoon SK, Mehta S.

Source

Division of Infectious Diseases, University of California, San Diego, School of

Medicine, La Jolla, California.

Abstract

The virologic determinants of progressive liver disease associated with

hepatitis B virus (HBV) remain unclear. Previous investigations have associated

HBV disease with specific mutations but this association may be confounded by

HBV genotype, HLA haplotype of the infected individual or both. The association

between non-synonymous mutations located within putative cytotoxic T-lymphocyte

directed epitopes (CDE) of the HBV core region and disease states was

investigated. Subjects infected with HBV were enrolled from a clinical cohort in

Seoul, Korea, and HBV core gene sequences were analyzed for mutational patterns

inside and outside of CDE with respect to subject demographics and HBV-related

disease states. No specific mutation or pattern of mutations were associated

with progressive disease states; however, individuals with cirrhosis and

hepatocellular carcinoma had greater numbers of non-synonymous mutations within

CDE when compared to those with chronic HBV infection who were HBeAg positive

(P = 0.007 and 0.026, respectively). In conclusion, this study demonstrates

that HBV disease progression is associated with viral escape mutations that are

a marker of CTL activity. These data suggest that the number of non-synonymous

mutations in the HBV core region may predict HBV disease progression better than

any single mutation or pattern of mutations. J. Med. Virol. 83:2082-2087, 2011.

© 2011 Wiley Periodicals, Inc.

Copyright © 2011 Wiley Periodicals, Inc.

PMID: 22012714 [PubMed - in process]