Virucidal activity of ortho-phthalaldehyde solutions against hepatitis B and C viruses

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Brief report

Virucidal activity of ortho-phthalaldehyde solutions against hepatitis B and C

viruses

G. MS, a, , Harriet B. Chan-Myers BSa and S. Favero PhDa

aAdvanced Sterilization Products, and Company, Irvine, CA

Available online 24 March 2008.

Ortho-phthalaldehyde (OPA), a high-level disinfectant alternative to

glutaraldehyde, was tested for efficacy against human hepatitis B virus (HBV)

and hepatitis C virus (HCV) using surrogate animal viruses. HBV and HCV are the

most prevalent human bloodborne viruses but have not yet been propagated in the

laboratory. The surrogate viruses, duck hepatitis B virus (DHBV) and bovine

viral diarrhea virus (BVDV), were used to assess the virucidal efficacy of OPA

on HBV and HCV, respectively. After a timed exposure to the test disinfectant,

the surrogate virus dried on a hard surface was neutralized and assayed to

detect viable viruses using appropriate cell lines. A greater than 4-log10

reduction in virus titer was demonstrated using dilute OPA solutions against

dried DHBV and BVDV after 5 minutes of exposure at 20°C. OPA was shown to be

efficacious against surrogate viruses for human hepatitis B and hepatitis C

virus. This is the first time that OPA efficacy has been demonstrated for HBV

and HCV.

Address correspondence to G. , MS, Advanced Sterilization

Products, 33 Technology Drive, Irvine, CA 92618.

American Journal of Infection Control

Volume 36, Issue 3, April 2008, Pages 223-226

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6W9M-4S4D8DP-G & _user=1\

0 & _coverDate=04%2F30%2F2008 & _rdoc=14 & _fmt=summary & _orig=browse & _srch=doc-info(%2\

3toc%236686%232008%23999639996%23683788%23FLA%23display%23Volume) & _cdi=6686 & _sor\

t=d & _docanchor= & _ct=17 & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=\

8b2dee8701558c7a55474ce2fba96eaa

_________________________________________________________________

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[Guest guest]

Brief report

Virucidal activity of ortho-phthalaldehyde solutions against hepatitis B and C

viruses

G. MS, a, , Harriet B. Chan-Myers BSa and S. Favero PhDa

aAdvanced Sterilization Products, and Company, Irvine, CA

Available online 24 March 2008.

Ortho-phthalaldehyde (OPA), a high-level disinfectant alternative to

glutaraldehyde, was tested for efficacy against human hepatitis B virus (HBV)

and hepatitis C virus (HCV) using surrogate animal viruses. HBV and HCV are the

most prevalent human bloodborne viruses but have not yet been propagated in the

laboratory. The surrogate viruses, duck hepatitis B virus (DHBV) and bovine

viral diarrhea virus (BVDV), were used to assess the virucidal efficacy of OPA

on HBV and HCV, respectively. After a timed exposure to the test disinfectant,

the surrogate virus dried on a hard surface was neutralized and assayed to

detect viable viruses using appropriate cell lines. A greater than 4-log10

reduction in virus titer was demonstrated using dilute OPA solutions against

dried DHBV and BVDV after 5 minutes of exposure at 20°C. OPA was shown to be

efficacious against surrogate viruses for human hepatitis B and hepatitis C

virus. This is the first time that OPA efficacy has been demonstrated for HBV

and HCV.

Address correspondence to G. , MS, Advanced Sterilization

Products, 33 Technology Drive, Irvine, CA 92618.

American Journal of Infection Control

Volume 36, Issue 3, April 2008, Pages 223-226

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6W9M-4S4D8DP-G & _user=1\

0 & _coverDate=04%2F30%2F2008 & _rdoc=14 & _fmt=summary & _orig=browse & _srch=doc-info(%2\

3toc%236686%232008%23999639996%23683788%23FLA%23display%23Volume) & _cdi=6686 & _sor\

t=d & _docanchor= & _ct=17 & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=\

8b2dee8701558c7a55474ce2fba96eaa

_________________________________________________________________

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