The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis

[Guest guest]

Arch Virol. 2008;153(11):2157-61. Epub 2008 Nov 1.

The distribution of HBV genotypes and clinical significance in familial

clustering in an infected population with unfavorable prognosis.

Liu J, Li Y, Chen T, Yang Y, Wang K, He Y, Yang Q, Ye F, Jin Y, Qiu T, Lin S,

Liu M, Zhao Y.

Department of Infectious Diseases, The First Affiliated Hospital of Xi'an

JiaoTong University School of Medicine, 710061, Xi'an, Shaanxi Province, China.

sourmilk2003@...

Using a nested-PCR genotyping system, we analyzed the viral genotypes in

HBV-infected patients from HBV clustering infection families (CIFs), as compared

with HBV infected patients without familial infection history. The patients in

the CIF group showed significantly increased prevalence of genotype C infection,

while genotype B was absent. Additionally, in the genotype C carriers younger

than 50 years old, the prevalence of HCC and LC were significantly increased in

CIF compared to the control. We found that HBeAg-positive HBV genotype C

carriers are prone to develop end-stage liver diseases earlier than those

infected by genotype B.

PMID: 18982245 [PubMed - indexed for MEDLINE

[Guest guest]

Arch Virol. 2008;153(11):2157-61. Epub 2008 Nov 1.

The distribution of HBV genotypes and clinical significance in familial

clustering in an infected population with unfavorable prognosis.

Liu J, Li Y, Chen T, Yang Y, Wang K, He Y, Yang Q, Ye F, Jin Y, Qiu T, Lin S,

Liu M, Zhao Y.

Department of Infectious Diseases, The First Affiliated Hospital of Xi'an

JiaoTong University School of Medicine, 710061, Xi'an, Shaanxi Province, China.

sourmilk2003@...

Using a nested-PCR genotyping system, we analyzed the viral genotypes in

HBV-infected patients from HBV clustering infection families (CIFs), as compared

with HBV infected patients without familial infection history. The patients in

the CIF group showed significantly increased prevalence of genotype C infection,

while genotype B was absent. Additionally, in the genotype C carriers younger

than 50 years old, the prevalence of HCC and LC were significantly increased in

CIF compared to the control. We found that HBeAg-positive HBV genotype C

carriers are prone to develop end-stage liver diseases earlier than those

infected by genotype B.

PMID: 18982245 [PubMed - indexed for MEDLINE