The change of the quantitative HBsAg level during the natural course of chronic hepatitis B

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The change of the quantitative HBsAg level during the natural course of chronic

hepatitis B

Liver International, 06/20/2011

Kim YJ et al. - The HBsAg level varied significantly in different phases of

chronic hepatitis B (CHB) and was correlated with hepatitis B virus (HBV) DNA

during the immune tolerance (IT), HBeAg-positive hepatitis (EPH) and inactive

carrier (IC) phases.

Methods • Retrospective cross-sectional study

• 645 treatment-naive Korean CHB patients

• They were categorized into

â—¦ immune tolerance (IT, n=56)

â—¦ HBeAg-positive hepatitis (EPH, n=150)

â—¦ inactive carrier (IC, n=274)

â—¦ HBeAg-negative hepatitis (ENH, n=165)

• The baseline HBsAg and HBV DNA levels were measured.

•

Results • The mean HBsAg titres (log IU/ml) differed (P<0.001): IT 4.29, EPH

3.64, IC 2.05 and ENH 3.23.

• In 645 patients, HBsAg and HBV DNA showed a significant correlation

(r=0.693, P<0.001), and this was also observed in the IT, EPH and IC groups

(r=0.664, r=0.541, r=0.505, respectively, all P<0.001), but not in the ENH group

(r=0.093, P=0.321).

• Age had a negative correlation with HBsAg (r=-0.451, P<0.001).

• The cirrhotic patients had a significantly lower HBsAg level than the

non-cirrhotic patients (2.41 ± 1.36 vs. 3.02 ± 1.21 log IU/ml, P<0.001).

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http://www.ingentaconnect.com/content/mksg/liv/2011/00000031/00000006/art00010

The change of the quantitative HBsAg level during the natural course of chronic

hepatitis B

Authors: Kim, Yu J.; Cho, Hyun C.; Choi, Moon S.; Lee, Joon H.; Koh, Kwang C.;

Yoo, Byung C.; Paik, Seung W.

Source: Liver International, Volume 31, Number 6, July 2011 , pp. 817-823(7)

Publisher: Wiley-Blackwell

Abstract:

Background:

There is insufficient information about HBsAg levels and their correlation with

serum hepatitis B virus (HBV) DNA in chronic hepatitis B (CHB).

Aims:

We aimed to describe HBsAg levels during various phases of CHB and to

investigate the correlation with serum HBV DNA levels.

Methods:

A total of 645 treatment-naïve Korean CHB patients were included in this

retrospective cross-sectional study. They were categorized into immune tolerance

(IT, n=56), HBeAg-positive hepatitis (EPH, n=150), inactive carrier (IC, n=274)

and HBeAg-negative hepatitis (ENH, n=165). The baseline HBsAg and HBV DNA levels

were measured.

Results:

The mean HBsAg titres (log IU/ml) differed (P<0.001): IT 4.29, EPH 3.64, IC 2.05

and ENH 3.23. In 645 patients, HBsAg and HBV DNA showed a significant

correlation (r=0.693, P<0.001), and this was also observed in the IT, EPH and IC

groups (r=0.664, r=0.541, r=0.505, respectively, all P<0.001), but not in the

ENH group (r=0.093, P=0.321). Age had a negative correlation with HBsAg

(r=−0.451, P<0.001). The cirrhotic patients had a significantly lower HBsAg

level than the non-cirrhotic patients (2.41 ± 1.36 vs. 3.02 ±

1.21 log IU/ml, P<0.001).

Conclusions:

The HBsAg level varied significantly in different phases of CHB and was

correlated with HBV DNA during the IT, EPH and IC phases. These findings can

provide additional information to understand the natural course and pathogenesis

of CHB.

Document Type: Research article

DOI: 10.1111/j.1478-3231.2011.02516.x

Affiliations:1: Department of Medicine, Samsung Medical Center, Sungkyunkwan

University School of Medicine, Seoul, Korea

Publication date: 2011-07-01

[Guest guest]

http://www.mdlinx.com/gastroenterology/newsl-article.cfm/3636192/ZZ6806553679256\

39220014/?news_id=511 & newsdt=062011 & subspec_id=144

The change of the quantitative HBsAg level during the natural course of chronic

hepatitis B

Liver International, 06/20/2011

Kim YJ et al. - The HBsAg level varied significantly in different phases of

chronic hepatitis B (CHB) and was correlated with hepatitis B virus (HBV) DNA

during the immune tolerance (IT), HBeAg-positive hepatitis (EPH) and inactive

carrier (IC) phases.

Methods • Retrospective cross-sectional study

• 645 treatment-naive Korean CHB patients

• They were categorized into

â—¦ immune tolerance (IT, n=56)

â—¦ HBeAg-positive hepatitis (EPH, n=150)

â—¦ inactive carrier (IC, n=274)

â—¦ HBeAg-negative hepatitis (ENH, n=165)

• The baseline HBsAg and HBV DNA levels were measured.

•

Results • The mean HBsAg titres (log IU/ml) differed (P<0.001): IT 4.29, EPH

3.64, IC 2.05 and ENH 3.23.

• In 645 patients, HBsAg and HBV DNA showed a significant correlation

(r=0.693, P<0.001), and this was also observed in the IT, EPH and IC groups

(r=0.664, r=0.541, r=0.505, respectively, all P<0.001), but not in the ENH group

(r=0.093, P=0.321).

• Age had a negative correlation with HBsAg (r=-0.451, P<0.001).

• The cirrhotic patients had a significantly lower HBsAg level than the

non-cirrhotic patients (2.41 ± 1.36 vs. 3.02 ± 1.21 log IU/ml, P<0.001).

------------------------------------------------------------------------

http://www.ingentaconnect.com/content/mksg/liv/2011/00000031/00000006/art00010

The change of the quantitative HBsAg level during the natural course of chronic

hepatitis B

Authors: Kim, Yu J.; Cho, Hyun C.; Choi, Moon S.; Lee, Joon H.; Koh, Kwang C.;

Yoo, Byung C.; Paik, Seung W.

Source: Liver International, Volume 31, Number 6, July 2011 , pp. 817-823(7)

Publisher: Wiley-Blackwell

Abstract:

Background:

There is insufficient information about HBsAg levels and their correlation with

serum hepatitis B virus (HBV) DNA in chronic hepatitis B (CHB).

Aims:

We aimed to describe HBsAg levels during various phases of CHB and to

investigate the correlation with serum HBV DNA levels.

Methods:

A total of 645 treatment-naïve Korean CHB patients were included in this

retrospective cross-sectional study. They were categorized into immune tolerance

(IT, n=56), HBeAg-positive hepatitis (EPH, n=150), inactive carrier (IC, n=274)

and HBeAg-negative hepatitis (ENH, n=165). The baseline HBsAg and HBV DNA levels

were measured.

Results:

The mean HBsAg titres (log IU/ml) differed (P<0.001): IT 4.29, EPH 3.64, IC 2.05

and ENH 3.23. In 645 patients, HBsAg and HBV DNA showed a significant

correlation (r=0.693, P<0.001), and this was also observed in the IT, EPH and IC

groups (r=0.664, r=0.541, r=0.505, respectively, all P<0.001), but not in the

ENH group (r=0.093, P=0.321). Age had a negative correlation with HBsAg

(r=−0.451, P<0.001). The cirrhotic patients had a significantly lower HBsAg

level than the non-cirrhotic patients (2.41 ± 1.36 vs. 3.02 ±

1.21 log IU/ml, P<0.001).

Conclusions:

The HBsAg level varied significantly in different phases of CHB and was

correlated with HBV DNA during the IT, EPH and IC phases. These findings can

provide additional information to understand the natural course and pathogenesis

of CHB.

Document Type: Research article

DOI: 10.1111/j.1478-3231.2011.02516.x

Affiliations:1: Department of Medicine, Samsung Medical Center, Sungkyunkwan

University School of Medicine, Seoul, Korea

Publication date: 2011-07-01