Non-specific and sex-differential effects of routine vaccines

[Guest guest]

Aaby has >400 studies indexed by PubMed. His

findings are fraught with significance, eg:

Non-specific and

sex-differential effects of routine vaccines: What evidence is needed to

take these effects into consideration in low-income countries?

http://www.ncbi.nlm.nih.gov/pubmed/21278492

Aaby P, Benn CS.

Hum Vaccin. 2011 Jan 1;7(1):120-4.

None of the original vaccines used in the child immunization programmes

in low-income countries, including BCG, diphtheria-tetanus-pertussis

(DTP), oral polio vaccine (OPV), and measles vaccine (MV), were tested

for their overall effect on child mortality before being introduced. It

was assumed that the effect on overall child mortality would be

equivalent to the proportion of deaths caused by the targeted disease(s)

(1). However, this is no longer a tenable assumption. Many studies have

shown that these routine vaccines may have more general effects on the

immune system than merely protecting against the targeted disease, i.e.

so-called non-specific effects (NSE) (2). The NSE may well be more

important for overall child survival than the lives saved by specific

disease prevention (2-4).

The WHO´s Global Advisory Committee on Vaccine Safety (GACVS) has

recently stated that it will keep a watch on the non-specific effects

(NSE) of vaccination. GACVS indicated that " conclusive evidence for

or against non-specific effects of vaccines on mortality, including a

potential deleterious effect of DTP vaccination on children's survival as

has been reported in some studies, was unlikely to be obtained from

observational studies " (5). By insisting on new RCTs to provide

conclusive evidence, GACVS is making it very difficult if not impossible

to test the NSEs of the currently recommended vaccines. It would usually

be considered unethical to test currently recommended vaccines as part of

a trial withholding these vaccines from some children (6).

see also:

BBC: The Vaccine Detectives Part One

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode34

(scroll nearly all the way down the page)

BBC: The Vaccine Detectives Part Two

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode33

(scroll nearly all the way down the page)

excerpt from a Mercola essay:

Clearly, Dr. Aaby has science-based information that could change

public healthcare forever – and perhaps even change the vaccine schedule

for infants in the U.S. But before you read any further, I urge you to

click on the links above and listen to both segments of the BBC's

broadcast, The Vaccine Detectives....

A single dose of DTP vaccine not only doubled the mortality

rate in infants, but more than quadruped the rate after the

second and third DTP doses. Vaccines and vitamin supplements have unexpected, long-term effects –

good and bad – on the immune systems of children. There is a definite increased mortality risk to girls of

combining DTP and measles vaccines. Girls were 41 percent more likely to die if they were given

vitamin A at birth, while boys seemed to slightly benefit from the

supplement. from

here

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode33

[Guest guest]

Aaby has >400 studies indexed by PubMed. His

findings are fraught with significance, eg:

Non-specific and

sex-differential effects of routine vaccines: What evidence is needed to

take these effects into consideration in low-income countries?

http://www.ncbi.nlm.nih.gov/pubmed/21278492

Aaby P, Benn CS.

Hum Vaccin. 2011 Jan 1;7(1):120-4.

None of the original vaccines used in the child immunization programmes

in low-income countries, including BCG, diphtheria-tetanus-pertussis

(DTP), oral polio vaccine (OPV), and measles vaccine (MV), were tested

for their overall effect on child mortality before being introduced. It

was assumed that the effect on overall child mortality would be

equivalent to the proportion of deaths caused by the targeted disease(s)

(1). However, this is no longer a tenable assumption. Many studies have

shown that these routine vaccines may have more general effects on the

immune system than merely protecting against the targeted disease, i.e.

so-called non-specific effects (NSE) (2). The NSE may well be more

important for overall child survival than the lives saved by specific

disease prevention (2-4).

The WHO´s Global Advisory Committee on Vaccine Safety (GACVS) has

recently stated that it will keep a watch on the non-specific effects

(NSE) of vaccination. GACVS indicated that " conclusive evidence for

or against non-specific effects of vaccines on mortality, including a

potential deleterious effect of DTP vaccination on children's survival as

has been reported in some studies, was unlikely to be obtained from

observational studies " (5). By insisting on new RCTs to provide

conclusive evidence, GACVS is making it very difficult if not impossible

to test the NSEs of the currently recommended vaccines. It would usually

be considered unethical to test currently recommended vaccines as part of

a trial withholding these vaccines from some children (6).

see also:

BBC: The Vaccine Detectives Part One

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode34

(scroll nearly all the way down the page)

BBC: The Vaccine Detectives Part Two

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode33

(scroll nearly all the way down the page)

excerpt from a Mercola essay:

Clearly, Dr. Aaby has science-based information that could change

public healthcare forever – and perhaps even change the vaccine schedule

for infants in the U.S. But before you read any further, I urge you to

click on the links above and listen to both segments of the BBC's

broadcast, The Vaccine Detectives....

A single dose of DTP vaccine not only doubled the mortality

rate in infants, but more than quadruped the rate after the

second and third DTP doses. Vaccines and vitamin supplements have unexpected, long-term effects –

good and bad – on the immune systems of children. There is a definite increased mortality risk to girls of

combining DTP and measles vaccines. Girls were 41 percent more likely to die if they were given

vitamin A at birth, while boys seemed to slightly benefit from the

supplement. from

here

http://www.bbc.co.uk/podcasts/series/discovery/all#playepisode33