Coffee Consumption is Associated with Response to Peginterferon and Ribavirin Therapy in Patients with Chronic Hepatitis C.

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Gastroenterology. 2011 Mar 1. [Epub ahead of print]

Coffee Consumption is Associated with Response to Peginterferon and Ribavirin

Therapy in Patients with Chronic Hepatitis C.

Freedman ND, Curto TM, KL, EC, Sinha R, Everhart JE; HALT-C Trial

Group.

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, National Institutes of Health, Department of Health

and Human Services, Rockville, MD.

Abstract

BACKGROUND & AIMS: High level coffee consumption has been associated with

reduced progression of pre-existing liver diseases and lower risk of

hepatocellular carcinoma. However, its relationship with therapy for Hepatitis C

virus (HCV) infection has not been evaluated.

METHODS: Patients (n=885) from the lead-in phase of the Hepatitis C Antiviral

Long-Term Treatment Against Cirrhosis (HALT-C) trial recorded coffee intake

before re-treatment with peginterferon alfa-2a (180 μg/wk) and ribavirin

(1000-1200 mg/day). We assessed patients for early virologic response (EVR, 2

log(10) reduction in level of HCV RNA at week 12; n=466) and undetectable HCV

RNA at week 20 (W20VR; n=320), week 48 (end of treatment, EOT; n=284), and week

72 (sustained virologic response, SVR; n=157).

RESULTS: The median log(10) drop from baseline to week 20 was 2.0 (interquartile

range: 0.6-3.9) among non-drinkers and 4.0 (2.1-4.7) among patients that drank

≥3 cup/day of coffee (P-trend <0.0001). In unadjusted models, the odds ratios

(OR) and 95% confidence intervals (CI) for drinking ≥3 cups/day vs

non-drinking were 3.2 (1.9-5.3) for EVR, 3.1 (1.8-5.1) for W20VR, 3.5 (2.0-5.9)

for EOT, and 2.7 (1.4-5.3) for SVR (P-trend<0.0001 for all). After adjustment

for age, race/ethnicity, sex, alcohol, cirrhosis, ratio of aspartate

aminotransferase:alanine aminotransferase, the IL28B polymorphism rs12979860,

dose reduction of peginterferon, and other covariates, the OR (95% CI) for EVR

was 2.0 (1.1-3.6; P-trend = 0.004); for W20VR was 2.1 (1.1-3.9; p-trend=0.005);

for EOT was 2.4 (1.3-4.6; P-trend=0.001), and for SVR was 1.8 (0.8-3.9;

P-trend=0.034).

CONCLUSION: High-level consumption of coffee (more than 3 cups per day) is an

independent predictor of improved virologic response to peginterferon plus

ribavirin in patients with Hepatitis C.Copyright © 2011 AGA Institute.

Published by Elsevier Inc. All rights reserved.

PMID: 21376050 [PubMed - as supplied by publisher]

[Guest guest]

Gastroenterology. 2011 Mar 1. [Epub ahead of print]

Coffee Consumption is Associated with Response to Peginterferon and Ribavirin

Therapy in Patients with Chronic Hepatitis C.

Freedman ND, Curto TM, KL, EC, Sinha R, Everhart JE; HALT-C Trial

Group.

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics,

National Cancer Institute, National Institutes of Health, Department of Health

and Human Services, Rockville, MD.

Abstract

BACKGROUND & AIMS: High level coffee consumption has been associated with

reduced progression of pre-existing liver diseases and lower risk of

hepatocellular carcinoma. However, its relationship with therapy for Hepatitis C

virus (HCV) infection has not been evaluated.

METHODS: Patients (n=885) from the lead-in phase of the Hepatitis C Antiviral

Long-Term Treatment Against Cirrhosis (HALT-C) trial recorded coffee intake

before re-treatment with peginterferon alfa-2a (180 μg/wk) and ribavirin

(1000-1200 mg/day). We assessed patients for early virologic response (EVR, 2

log(10) reduction in level of HCV RNA at week 12; n=466) and undetectable HCV

RNA at week 20 (W20VR; n=320), week 48 (end of treatment, EOT; n=284), and week

72 (sustained virologic response, SVR; n=157).

RESULTS: The median log(10) drop from baseline to week 20 was 2.0 (interquartile

range: 0.6-3.9) among non-drinkers and 4.0 (2.1-4.7) among patients that drank

≥3 cup/day of coffee (P-trend <0.0001). In unadjusted models, the odds ratios

(OR) and 95% confidence intervals (CI) for drinking ≥3 cups/day vs

non-drinking were 3.2 (1.9-5.3) for EVR, 3.1 (1.8-5.1) for W20VR, 3.5 (2.0-5.9)

for EOT, and 2.7 (1.4-5.3) for SVR (P-trend<0.0001 for all). After adjustment

for age, race/ethnicity, sex, alcohol, cirrhosis, ratio of aspartate

aminotransferase:alanine aminotransferase, the IL28B polymorphism rs12979860,

dose reduction of peginterferon, and other covariates, the OR (95% CI) for EVR

was 2.0 (1.1-3.6; P-trend = 0.004); for W20VR was 2.1 (1.1-3.9; p-trend=0.005);

for EOT was 2.4 (1.3-4.6; P-trend=0.001), and for SVR was 1.8 (0.8-3.9;

P-trend=0.034).

CONCLUSION: High-level consumption of coffee (more than 3 cups per day) is an

independent predictor of improved virologic response to peginterferon plus

ribavirin in patients with Hepatitis C.Copyright © 2011 AGA Institute.

Published by Elsevier Inc. All rights reserved.

PMID: 21376050 [PubMed - as supplied by publisher]