The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients

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Eur J Gastroenterol Hepatol. 2008 Jul;20(7):668-73.

The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus

patients.

Demir M, Serin E, Göktürk S, Ozturk NA, Kulaksizoglu S, Ylmaz U.

Departments of aGastroenterology bBiochemistry, Baºkent University Faculty of

Medicine, Konya, Turkey.

AIM: The prevalence of occult hepatitis B virus (HBV) infection is relatively

frequent among patients with immune suppression. The impairment of the immune

system is well demonstrated in diabetics. We aimed to investigate the prevalence

of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B

surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.

MATERIALS AND METHODS: The study involved 100 HBcAb+/-anti-HBs type 2 diabetes

mellitus patients and 100 age and sex matched, HBcAb+/-anti-HBs healthy blood

donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus

or HIV, diagnosis of malignancy or earlier organ transplantation history, use of

immunosuppressive therapy. All patients were questioned about their past medical

history and were tested for serum alanine aminotransferase and HBV DNA level.

RESULTS: The diabetic patients did not differ significantly from healthy

controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic

patients (1 x 10-5 x 10 copies/ml) and in 3% of the controls (4 x 10-1 x 10

copies/ml). The difference between groups was statistically significant (P0.05).

The serum alanine aminotransferase levels in diabetic patients were close to

those of controls (26.2+/-16.4 IU/l vs. 23.9+/-9.7 IU/l; P>0.05). CONCLUSION:

These data suggest that the prevalence of occult HBV infection is higher in

diabetics compared with healthy controls and this may contribute to the

increased prevalence of primary hepatocellular carcinoma in diabetics.

PMID: 18679070 [PubMed - in process]

[Guest guest]

Eur J Gastroenterol Hepatol. 2008 Jul;20(7):668-73.

The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus

patients.

Demir M, Serin E, Göktürk S, Ozturk NA, Kulaksizoglu S, Ylmaz U.

Departments of aGastroenterology bBiochemistry, Baºkent University Faculty of

Medicine, Konya, Turkey.

AIM: The prevalence of occult hepatitis B virus (HBV) infection is relatively

frequent among patients with immune suppression. The impairment of the immune

system is well demonstrated in diabetics. We aimed to investigate the prevalence

of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B

surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.

MATERIALS AND METHODS: The study involved 100 HBcAb+/-anti-HBs type 2 diabetes

mellitus patients and 100 age and sex matched, HBcAb+/-anti-HBs healthy blood

donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus

or HIV, diagnosis of malignancy or earlier organ transplantation history, use of

immunosuppressive therapy. All patients were questioned about their past medical

history and were tested for serum alanine aminotransferase and HBV DNA level.

RESULTS: The diabetic patients did not differ significantly from healthy

controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic

patients (1 x 10-5 x 10 copies/ml) and in 3% of the controls (4 x 10-1 x 10

copies/ml). The difference between groups was statistically significant (P0.05).

The serum alanine aminotransferase levels in diabetic patients were close to

those of controls (26.2+/-16.4 IU/l vs. 23.9+/-9.7 IU/l; P>0.05). CONCLUSION:

These data suggest that the prevalence of occult HBV infection is higher in

diabetics compared with healthy controls and this may contribute to the

increased prevalence of primary hepatocellular carcinoma in diabetics.

PMID: 18679070 [PubMed - in process]